A unusual brain cortical tumor: angiocentric glioma

Annales de pathologie
Arnault Tauziède-EspariatMarc Polivka

Abstract

We report the case of an 11-year-old girl, who was admitted for surgery of an epilepsy-associated brain tumor. The radiological and clinical hypothesis was dysembryoplasic neuroepithelial tumor. Histopathological examination revealed a tumoral proliferation composed of spindle-shaped cells with palisade arrangements around vessels. Tumor cells have small, round and regular nuclei without atypia or mitosis. On immunohistochemistry, the neoplastic cells strongly expressed GFAP and showed a characteristic cytoplasmic dot-like staining with EMA (epithelial membrane antigen). Ki-67 labeling index was low. Molecular analysis failed to reveal the V600E mutation of BRAF gene. The patient was free of seizures after surgery. Angiocentric glioma is a rare brain tumor occuring preferably in children and young adults and is associated with seizures. The precise histogenesis remains debated. The treatment of choice is total resection. The prognosis is favorable if totally resected.

References

Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Apr 3, 2009·Journal of Neurosurgery. Pediatrics·Sophia F ShakurGeorge I Jallo
Mar 27, 2012·Annals of Diagnostic Pathology·Aditya RaghunathanGregory N Fuller
Oct 18, 2012·Clinical Neuropathology·Anna Maria BuccolieroGian Luigi Taddei
Feb 5, 2013·Journal of Radiology Case Reports·Hector N AguilarTrevor Kotylak

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Citations

Apr 2, 2021·Journal of Molecular Neuroscience : MN·Hang XingPeter David Koch

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