A validated genome-wide association study in 2 dairy cattle breeds for milk production and fertility traits using variable length haplotypes

Journal of Dairy Science
J E PryceB J Hayes

Abstract

Genome-wide association studies (GWAS) were used to discover genomic regions explaining variation in dairy production and fertility traits. Associations were detected with either single nucleotide polymorphism (SNP) markers or haplotypes of SNP alleles. An across-breed validation strategy was used to narrow the genomic interval containing causative mutations. There were 39,048 SNP tested in a discovery population of 780 Holstein sires and validated in 386 Holsteins and 364 Jersey sires. Previously identified mutations affecting milk production traits were confirmed. In addition, several novel regions were identified, including a putative quantitative trait loci for fertility on chromosome 18 that was detected only using haplotypes greater than 3 SNP long. It was found that the precision of quantitative trait loci mapping increased with haplotype length as did the number of validated haplotypes discovered, especially across breed. Promising candidate genes have been identified in several of the validated regions.

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Citations

Mar 24, 2012·Animal : an International Journal of Animal Bioscience·D P BerryC J Creevey
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·D P Berry, J F Kearney
Jul 20, 2013·Genetics, Selection, Evolution : GSE·Lesley-Ann RavenBen J Hayes
May 17, 2011·BMC Genetics·Aniek C BouwmanJohan A M van Arendonk
Oct 12, 2012·BMC Genomics·Rasmus Froberg BrøndumBenjamin J Hayes
Sep 11, 2012·Journal of Animal Science and Biotechnology·Hui ZhangHui Li
Nov 23, 2013·PloS One·Giulietta MinozziJohn L Williams
Jan 8, 2011·Genetics·Jennie E PryceMichael E Goddard
Apr 8, 2014·Animal : an International Journal of Animal Bioscience·D P BerryJ E Pryce
Jul 17, 2015·Molecular Ecology Resources·Robert R FitakPamela A Burger
May 3, 2012·Animal Genetics·J Y WangQ Zhang
Mar 13, 2012·Animal Genetics·J E PowellC S Haley
Nov 9, 2011·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M E GoddardT H E Meuwissen
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Oct 22, 2015·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·X MaoB Guldbrandtsen

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