A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts.

Journal of Analytical Methods in Chemistry
Renata Fabiane Jorge TiossiJairo Kenupp Bastos

Abstract

Solanum lycocarpum (Solanaceae) is native to the Brazilian Cerrado. Fruits of this species contain the glycoalkaloids solasonine (SN) and solamargine (SM), which display antiparasitic and anticancer properties. A method has been developed for the extraction and HPLC-UV analysis of the SN and SM in different parts of S. lycocarpum, mainly comprising ripe and unripe fruits, leaf, and stem. This analytical method was validated and gave good detection response with linearity over a dynamic range of 0.77-1000.00 μg mL(-1) and recovery in the range of 80.92-91.71%, allowing a reliable quantitation of the target compounds. Unripe fruits displayed higher concentrations of glycoalkaloids (1.04% ± 0.01 of SN and 0.69% ± 0.00 of SM) than the ripe fruits (0.83% ± 0.02 of SN and 0.60% ± 0.01 of SM). Quantitation of glycoalkaloids in the alkaloidic extract gave 45.09% ± 1.14 of SN and 44.37% ± 0.60 of SM, respectively.

References

Jul 14, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J T BlankemeyerM Friedman
Jun 18, 2002·Journal of Ethnopharmacology·Cláudia Veiga ChangVera Maria Peters
Sep 19, 2003·Phytotherapy Research : PTR·G VieiraE A Costa
Feb 1, 1987·Planta medica·B E Cham, L Wilson
Jul 14, 2007·Phytotherapy Research : PTR·Aline SchwarzHelenice de Souza Spinosa
Apr 20, 2010·Journal of Agricultural and Food Chemistry·María-Cortes Sánchez-MataJaime Prohens
Oct 23, 2010·Journal of Pharmaceutical and Biomedical Analysis·Karuna ShankerMadan M Gupta
Nov 26, 2010·Journal of Pharmaceutical and Biomedical Analysis·João Paulo B SousaJairo K Bastos

❮ Previous
Next ❯

Citations

Feb 11, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Renata F J TiossiJairo K Bastos
Jul 31, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Carla Carolina MunariDenise Crispim Tavares
Jan 10, 2013·Experimental Parasitology·Mariza Abreu MirandaJairo Kenupp Bastos
Apr 12, 2013·Chemistry & Biodiversity·Mariza Abreu MirandaJairo Kenupp Bastos

❮ Previous
Next ❯

Software Mentioned

Class VP

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Renata Fabiane Jorge TiossiJairo Kenupp Bastos
© 2021 Meta ULC. All rights reserved