A valve-less microfluidic peristaltic pumping method

Biomicrofluidics
Xiannian ZhangYanyi Huang

Abstract

We demonstrate a valve-less microfluidic peristaltic pumping method which enables the delivery of continuous nanoliter-scale flow with high precision. The fluid is driven by squeezing the microchannels embedded in a poly(dimethylsiloxane) device with rolling cams or bearings. We achieve continuous and uniform flow with velocity range from 1 to 500 nl/s, with outflow volume error within 3 nl. The devices show enhanced backpressure resistance up to 340 kPa. This method also shows great flexibility. By altering the channels' layout, emulsions and plugs can be generated easily. These low-cost and easy-to-fabricate micro-pumps offer novel approaches for liquid actuation in various microfluidic applications.

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Citations

Jul 30, 2015·Biomicrofluidics·Bryan HaslamGregory P Nordin
Feb 13, 2020·Tissue Engineering. Part B, Reviews·Sarah A HewesK Jane Grande-Allen
Feb 21, 2021·Analytica Chimica Acta·Joshua J DavisJames P Grinias
Apr 13, 2021·Biosensors & Bioelectronics·Mehdi MohammadiAmir Sanati-Nezhad

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