A variant in the fibrillin-3 gene is associated with TGF-β and inhibin B levels in women with polycystic ovary syndrome.

Fertility and Sterility
Nazia Raja-KhanR S Legro

Abstract

In an attempt to evaluate the association between allele 8 (A8) of D19S884 in the fibrillin-3 gene and circulating transforming growth factor (TGF) β and inhibin levels in women with polycystic ovary syndrome (PCOS), we studied 120 similarly aged women from families with PCOS and compared 40 women with PCOS who did not have A8 (A8- PCOS) with 40 women with PCOS who had A8 (A8+ PCOS) and 40 normally menstruating women who did not have either PCOS or A8 (A8- Non-PCOS). A8- PCOS is associated with higher levels of TGF-β1 compared with A8+ PCOS or A8- Non-PCOS, similar levels of TGF-β2 compared with A8+ PCOS but lower levels of TGF-β2 compared with A8- Non-PCOS, and lower levels of inhibin B and aldosterone compared with A8+ PCOS.

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Citations

Aug 22, 2014·Reproductive Biology and Endocrinology : RB&E·Reshef TalHenry E Malter
Nov 26, 2014·European Journal of Endocrinology·Simona GaberščekElisabeth Lerchbaum
Dec 24, 2010·The Biochemical Journal·Ian RobertsonPenny Handford
Jun 24, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Ying FangXiaokui Yang
Oct 20, 2012·Molecular and Cellular Endocrinology·Gülüm Kosova, Margrit Urbanek
Apr 16, 2013·Reproductive Sciences·Nazia Raja-KhanRichard S Legro
Feb 2, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Mariana Di PietroDalhia Abramovich
Oct 10, 2015·Journal of Cell Communication and Signaling·Karina A Zeyer, Dieter P Reinhardt
Oct 1, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hui LiPeter C K Leung
Mar 29, 2021·Life Sciences·Yogamaya D Prabhu, Abilash Valsala Gopalakrishnan
Apr 8, 2021·Reproductive Sciences·Matheus Credendio EirasCristiana Libardi Miranda Furtado

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