A variant of porcine thyroxine-binding globulin has reduced affinity for thyroxine and is associated with testis size

Biology of Reproduction
D J NonnemanJ J Ford

Abstract

The field of genomics applies the dissection of genetic differences toward an understanding of the biology of complex traits. Quantitative trait loci (QTL) for testis size, plasma FSH in boars, and body composition (backfat) have been identified near the centromere on the X chromosome in a Meishan-White Composite resource population. Since thyroid function affects Sertoli cell development and adult testis size in rodents, and thyroxine-binding globulin (TBG) maps to this region on the porcine X chromosome, TBG was a positional candidate gene for testis size. We discovered a polymorphism in exon 2 of the porcine TBG gene that results in an amino acid change of the consensus histidine to an asparagine. This single nucleotide polymorphism (SNP) resides in the ligand-binding domain of the mature polypeptide, and the Meishan allele is the conserved allele found in human, bovine, sheep, and rodent TBG. Binding studies indicate altered binding characteristics of the allelic variants of TBG with the asparagine (White Composite) isoform having significantly greater affinity for thyroxine than the histidine (Meishan) isoform. Alternate alleles in boars from the resource population are also significantly associated with testis weight. The...Continue Reading

References

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Citations

Oct 27, 2012·Yi chuan = Hereditas·Yun-Long MaXiang-Dong Ding
May 31, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Galia ZamaratskaiaOystein Andresen
Apr 10, 2007·Animal Reproduction Science·G J MacdonaldJ J Ford
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·K C CairesD J McLean
Nov 26, 2010·Molecular Biology Reports·Martin MasopustStanislav Cepica
Jan 1, 2014·Journal of Animal Science and Technology·María Elena FernándezJuan Pedro Liron

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Methods Mentioned

BETA
PCR
Genotyping

Software Mentioned

IMpRH
Consed
TWOPOINT
Phred
Phrap
Polyphred
CRIMAP
SAS

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