A ventral pontine pathway promotes rhythmic activity in the medulla of neonate mice

Neuroreport
V BordayJ Champagnat

Abstract

We have developed in new-born mice a ventral tilted-horizontal slice preparation for pontine stimulation and recording of spontaneous respiratory-like rhythmic trains of glutamatergic excitatory postsynaptic potentials (EPSPs) in medullary neurons. Electrical stimulations (10-50 Hz for 100-500 ms) of the caudal pontine reticular formation triggered a burst of EPSPs, recycling of the rhythmic activity and persistent increase of the rhythmic behaviour. These results identify a ventral pontine pathway that promotes rhythm generating mechanisms in the medulla and probably derives from a population of lateral reticular neurons identified in the embryonic hindbrain and eliminated after inactivation of the early developmental gene Krox-20.

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Citations

Feb 11, 2004·Progress in Biophysics and Molecular Biology·Caroline BordayMuriel Thoby-Brisson
Jun 14, 2000·Progress in Neurobiology·K BallanyiI Homma
Jul 11, 2002·Respiratory Physiology & Neurobiology·Fabrice ChatonnetGilles Fortin
Jun 18, 2003·Respiratory Physiology & Neurobiology·Caroline BordayGilles Fortin
Mar 12, 2002·The European Journal of Neuroscience·Fabrice ChatonnetJean Champagnat
Feb 25, 2003·Annual Review of Neuroscience·Jack L FeldmanEugene E Nattie
Jun 5, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Fusao KatoRyo Ikeda
Mar 15, 2006·Respiratory Physiology & Neurobiology·F ChatonnetJ Champagnat
Oct 6, 2005·Respiratory Physiology & Neurobiology·C BordayG Fortin
Jul 6, 2007·The European Journal of Neuroscience·Laura GuimarãesJean Champagnat
Sep 5, 2001·Nature Reviews. Neuroscience·S P Cordes

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