A versatile and injectable poly(methyl methacrylate) cement functionalized with quaternized chitosan-glycerophosphate/nanosized hydroxyapatite hydrogels

Materials Science & Engineering. C, Materials for Biological Applications
Man WangYining Wang

Abstract

Injectable polymethylmethacrylate (PMMA) bone cement is alluring because it allows a minimally invasive surgical approach, reducing both the cost of treatment and patient discomfort. However, several documented drawbacks have necessitated the design of a more versatile version with adorable properties for future application. In this study, to amend the bulk behavior of PMMA cement, we synthesized a modified version by combining PMMA with quaternized chitosan (N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride, HTCC)-based hydrogels loaded with nanosized hydroxyapatite (Nano-HA). Then, the physicochemical properties, antimicrobial properties, remineralization capacity and mechanical performance changes under imitated physiological conditions were tested for these cements using a type K thermocouple, scanning electron microscope (SEM), microcomputed tomography (μ-CT), calcium ion test kit and mechanical compression tests. The results demonstrated that the HTCC-GP thermosensitive hydrogel generated interconnected pores, lower the Tmax value, lengthened the working time, developed appropriate mechanical properties and imparted excellent antibacterial activity to the cement. The Nano-HA particles engendered improved biominera...Continue Reading

Citations

Jul 28, 2020·Polymers·Mayra Eliana Valencia ZapataCarlos David Grande Tovar
Dec 4, 2020·Biomolecules·Mayra Eliana Valencia ZapataJosé Herminsul Mina Hernandez
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·K LavanyaN Selvamurugan

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