A Versatile AuNP Synthetic Platform for Decoupled Control of Size and Surface Composition

Langmuir : the ACS Journal of Surfaces and Colloids
Ye YangStefan Guldin

Abstract

While a plethora of protocols exist for the synthesis of sub-10-nm gold nanoparticles (AuNPs), independent control over the size and surface composition remains restricted. This poses a particular challenge for systematic studies of AuNP structure-function relationships and the optimization of crucial design parameters. To this end, we report on a modular two-step approach based on the synthesis of AuNPs in oleylamine (OAm) followed by subsequent functionalization with thiol ligands and mixtures thereof. The synthesis of OAm-capped AuNPs enables fine-tuning of the core size in the range of 2-7 nm by varying the reaction temperature. The subsequent thiol-for-OAm ligand exchange allows a reliable generation of thiol-capped AuNPs with target surface functionality. The compatibility of this approach with a vast library of thiol ligands provides detailed control of the mixed ligand composition and solubility in a wide range of solvents ranging from water to hexane. This decoupled control over the AuNP core and ligand shell provides a powerful toolbox for the methodical screening of optimal design parameters and facile preparation of AuNPs with target properties.

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Citations

Feb 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Biagio De AngelisLuciano De Sio
Jul 20, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Pedro D OrtizEduardo Schott

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