A Versatile High Speed 250 MHz Pulse Imager for Biomedical Applications.

Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering
Boris EpelHoward J Halpern

Abstract

A versatile 250 MHz pulse electron paramagnetic resonance (EPR) instrument for imaging of small animals is presented. Flexible design of the imager hardware and software makes it possible to use virtually any pulse EPR imaging modality. A fast pulse generation and data acquisition system based on general purpose PCI boards performs measurements with minimal additional delays. Careful design of receiver protection circuitry allowed us to achieve very high sensitivity of the instrument. In this article we demonstrate the ability of the instrument to obtain three dimensional images using the electron spin echo (ESE) and single point imaging (SPI) methods. In a phantom that contains a 1 mM solution of narrow line (16 μT, peak-to-peak) paramagnetic spin probe we achieved an acquisition time of 32 seconds per image with a fast 3D ESE imaging protocol. Using an 18 minute 3D phase relaxation (T(2e)) ESE imaging protocol in a homogeneous sample a spatial resolution of 1.4 mm and a standard deviation of T(2e) of 8.5% were achieved. When applied to in vivo imaging this precision of T(2e) determination would be equivalent to 2 torr resolution of oxygen partial pressure in animal tissues.

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Citations

Sep 15, 2012·Journal of Magnetic Resonance·Sandra S Eaton, Gareth R Eaton
Dec 14, 2011·Journal of Magnetic Resonance·R AhmadL C Potter
Jan 7, 2010·Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering·V S SubramanianHoward J Halpern
Jul 15, 2015·Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering·Gage RedlerHoward J Halpern
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Boris EpelHoward J Halpern
Feb 13, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gage RedlerHoward J Halpern
Apr 2, 2015·Journal of Magnetic Resonance·Boris Epel, Howard J Halpern
Jul 24, 2012·Journal of Magnetic Resonance·J PalmerR Ahmad
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Aug 9, 2016·Journal of Magnetic Resonance·Anthony G ChristodoulouBoris Epel
Aug 29, 2017·Tissue Engineering. Part C, Methods·Mrignayani KotechaHoward Halpern
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Aug 24, 2019·Cell Biochemistry and Biophysics·Michal GonetMartyna Elas
Nov 21, 2017·Applied Magnetic Resonance·Subramanian V SundramoorthyHoward J Halpern
Feb 3, 2018·Applied Magnetic Resonance·George A RinardHoward J Halpern
Mar 27, 2018·Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering·Epel BorisHoward J Halpern
Jul 19, 2013·Cancer Research·Martyna ElasHoward J Halpern
May 15, 2012·Journal of Magnetic Resonance·R AhmadV V Khramtsov
Mar 30, 2021·Applied Magnetic Resonance·Howard J Halpern, Boris M Epel
Mar 12, 2010·Chemical Reviews·Rizwan Ahmad, Periannan Kuppusamy
Nov 12, 2018·International Journal of Radiation Oncology, Biology, Physics·Boris EpelHoward J Halpern

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