PMID: 6172881Jan 1, 1981Paper

A vertebrate-like blood--brain barrier, with intraganglionic blood channels and occluding junctions, in the scorpion

Tissue & Cell
N J LaneR F Bowerman

Abstract

India ink and ionic lanthanum injections have revealed that the central nervous system (CNS) of the scorpion possesses a highly vascularized cephalothoracic ganglionic mass. It, together with other abdominal ganglia which form a ventral nerve cord, are all ensheathed by an outer layer of modified glial, or perineurial, cells. These cells resemble those which line the blood channels permeating the CNS, in exhibiting both inverted gap and tight junctions. Although the latter show close or fused membrane appositions, lanthanum appears to penetrate past a number, but not all, of them. Freeze-fracturing reveals that these junctions are composed of E-face particles aligned into a network of rows, or ridges, which are frequently discontinuous, especially near the periphery of the perineurium. This produces a somewhat 'leaky' system but occlusion to tracers occurs ultimately, for in the CNS none can be found beyond the perineurium. The existence of this perineurial blood-brain barrier is also demonstrable electrophysiologically where cations such as Mg2+ are unable to penetrate beyond the perineurial layer although they can, it seems, leak in via the blood vascular system. Relative differences in tightness between the perineurium and t...Continue Reading

References

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Citations

Jan 1, 1986·Tissue & Cell·N E Flower
Jan 1, 1990·Tissue & Cell·R DallaiN J Lane
Mar 9, 2004·Micron : the International Research and Review Journal for Microscopy·José Eduardo SerrãoGustavo Ferreira Martins
Jan 1, 1991·Annals of the New York Academy of Sciences·N J Lane
May 9, 2014·Frontiers in Zoology·Bastian J Klußmann-FrickeChristian S Wirkner
Jun 28, 2012·Arthropod Structure & Development·B-J Klußmann-FrickeC S Wirkner
Jan 1, 1986·Annals of the New York Academy of Sciences·N J AbbottM Bundgaard
Nov 1, 1992·Journal of Veterinary Internal Medicine·J E Maddison
Jan 1, 1986·Anatomy and Embryology·E R Lacy, E Reale

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