A very high prevalence of low HDL cholesterol in Spanish patients with acute coronary syndromes.

Clinical Cardiology
Xavier PintóJuan Pedro-Botet

Abstract

Total and low-density lipoprotein cholesterol (LDL-C) concentrations in coronary artery disease have progressively declined, although high-density lipoprotein cholesterol (HDL-C) has not always been evaluated. The prevalence and related factors of low HDL-C in a cohort of Spanish patients with acute coronary syndromes (ACS) were assessed. Clinical and laboratory data registered at admission and at discharge of 648 patients admitted to coronary care units of 6 Spanish hospitals for ACS between January 2004 and September 2007 were analyzed. Low HDL-C (HDL-C < 1.04 mmol/L) was observed in 367 (56.6%) patients. Male gender, smoking, hypertension, diabetes, high body mass index, and triglycerides were related to low HDL-C. Female gender was the strongest protective factor against low HDL-C (0.619; 95% confidence interval [CI]: 0.410-0.934; P = 0.022), whereas high triglycerides (1.653; 95% CI: 1.323-2.064; P < 0.001) followed by previous ischemic disease (1.504; 95% CI: 1.073-2.110; P = 0.018) were the strongest factors associated with low HDL-C. One-third of patients were taking statins at admission, but only 2% were on fibrate therapy. A large increase in statin therapy, but not in other hypolipemiant drug therapy, between admissi...Continue Reading

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Citations

Jul 14, 2014·Revista clínica española·J Pedro-BotetUNKNOWN en nombre del grupo de investigadores EDICONDIS-ULISEA
Sep 15, 2014·Clinical Biochemistry·Abdelghani BounafaaAbdelouahed Khalil
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Jul 6, 2016·Wiener klinische Wochenschrift·Péter KoncsosGyörgy Paragh

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