PMID: 11900517Mar 20, 2002Paper

A view at the millennium: the efficiency of enzymatic catalysis

Accounts of Chemical Research
Thomas C Bruice

Abstract

Binding TS in preference to S and increasing TDeltaS++by freezing out motions in E X S and E X TS have been accepted as the driving forces in enzymatic catalysis; however, the smaller value of DeltaG++ for a one-substrate enzymatic reaction, as compared to its nonenzymatic counterpart, is generally the result of a smaller value of DeltaH++. Ground-state conformers (E X NACs) are formed in enzymatic reactions that structurally resemble E X TS. E X NACs are in thermal equilibrium with all other E X S conformers and are turnstiles through which substrate molecules must pass to arrive at the lowest-energy TS. TS in E X TS may or may not be bound tighter than NAC in E X NAC.

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Citations

Jul 20, 2010·Interdisciplinary Sciences, Computational Life Sciences·S MartíJ Bertrán
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