A view of sur/KIR6.X, KATP channels

Annual Review of Physiology
A P BabenkoJ Bryan

Abstract

ATP-sensitive potassium channels, termed KATP channels, link the electrical activity of cell membranes to cellular metabolism. These channels are heteromultimers of sulfonylurea receptor (SUR) and KIR6.X subunits associated with a 1:1 stoichiometry as a tetramer (SUR/KIR6.X forms the pores, whereas SUR regulates their activity. Changes in [ATP]i and [ADP]i gate the channel. The diversity of KATP channels results from the assembly of SUR and KIR6.X subtypes KIR6.1-based channels differ from KIR6.2 channels mainly by their smaller unitary conductance. SUR1- and SUR2-based channels are distinguished by their differential sensitivity to sulfonylureas, whereas SUR2A-based channels are distinguished from SUR2B channels by their differential sensitivity to diazoxide. Mutations that result in the loss of KATP channels in pancreatic beta-cells have been identified in SUR1 and KIR6.2. These mutations lead to familial hyperinsulinism. Understanding the mutations in SUR and KIR6.X is allowing insight into how these channels respond to nucleotides, sulfonylureas, and potassium channel openers, KCOs.

References

Nov 3, 1992·Biochemical Pharmacology·M Gopalakrishnan, D J Triggle
Dec 1, 1992·Pflügers Archiv : European journal of physiology·T Ohno-Shosaku, C Yamamoto
Jan 1, 1991·Neuroscience·J M Treherne, M L Ashford
Feb 22, 1991·Brain Research·S ZiniY Ben-Ari
Aug 1, 1991·Journal of Bioenergetics and Biomembranes·N W DavisP R Stanfield
Jan 1, 1991·Experimental Brain Research·K P Murphy, S A Greenfield
Nov 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·U PantenC Schwanstecher
Sep 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·R Weik, B Neumcke
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S MislerM L McDaniel
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J de WeilleM Lazdunski
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J R de WeilleM Lazdunski
Sep 1, 1989·The Journal of Physiology·F M Ashcroft, M Kakei
May 1, 1987·Canadian Journal of Physiology and Pharmacology·F J Alvarez-LeefmansS M Gamiño
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H BernardiM Lazdunski
Sep 1, 1988·Pflügers Archiv : European journal of physiology·A I McNivenC R House
Jul 1, 1988·Pflügers Archiv : European journal of physiology·I Findlay
Mar 15, 1982·Biochemical Pharmacology·N KaubischR E Offord
Jul 1, 1995·The Journal of General Physiology·C A DoupnikH A Lester
Apr 1, 1995·The American Journal of Physiology·M T Nelson, J M Quayle
Sep 1, 1994·The Journal of Membrane Biology·M Hussain, A C Wareham
May 1, 1994·Pflügers Archiv : European journal of physiology·X Xu, K S Lee
May 1, 1994·Pflügers Archiv : European journal of physiology·C Schwanstecher, U Panten
Oct 1, 1993·Neuropharmacology·I Niki, S J Ashcroft

❮ Previous
Next ❯

Citations

Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A W WolkoffB F Scharschmidt
Jun 2, 2000·Biochemical and Biophysical Research Communications·K TanabeK Ueda
Mar 23, 2010·The Journal of Membrane Biology·Keat-Eng NgAndrew Tinker
Aug 11, 2010·The Journal of Membrane Biology·Luís RatoPedro F Oliveira
Mar 7, 2006·Pflügers Archiv : European journal of physiology·R SurberK Benndorf
Jan 31, 2008·Pflügers Archiv : European journal of physiology·Yongping Chai, Yu-Fung Lin
Dec 25, 2012·Pflügers Archiv : European journal of physiology·Ervice PouokamMartin Diener
Jun 13, 2006·Cellular and Molecular Neurobiology·Myrian VelascoCarlos G Onetti
Sep 17, 2005·Journal of Bioenergetics and Biomembranes·Hossein Ardehali
Dec 5, 2003·Archives of Biochemistry and Biophysics·James D McCully, Sidney Levitsky
Feb 26, 2004·Bioorganic & Medicinal Chemistry Letters·Atul GoelVishnu J Ram
Dec 9, 2003·European Journal of Pharmacology·Takakazu YunokiYushi Ito
Nov 29, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hany GhalyIngo Rustenbeck
Dec 18, 2013·Journal of Plant Physiology·Daniel Prieto, Purificación Corchete
Jun 28, 2005·Journal of Molecular and Cellular Cardiology·Hossein Ardehali, Brian O'Rourke
Feb 28, 2003·The Annals of Thoracic Surgery·James D McCully, Sidney Levitsky
Feb 13, 2001·Biophysical Journal·D EnkvetchakulC G Nichols
Mar 10, 2000·European Journal of Pharmacology·C TerrenoireY Tourneur
Jun 16, 2000·European Journal of Pharmacology·Y UwaiK Inui
Aug 23, 2002·European Journal of Pharmacology·Daniela Alves, Igor Duarte
Feb 19, 2002·Mechanisms of Ageing and Development·Harri J RankiAleksandar Jovanović
Dec 12, 2002·Progress in Biophysics and Molecular Biology·Makoto Takano, Shinobu Kuratomi
Feb 5, 2003·Progress in Biophysics and Molecular Biology·Susumu Seino, Takashi Miki
May 14, 1999·Trends in Pharmacological Sciences·A Szewczyk, E Marbán
Aug 31, 2001·Journal of the American College of Cardiology·H J RankiA Jovanović
Jul 13, 1999·Neuron·D M Papazian
Aug 8, 2002·Journal of Pharmacological and Toxicological Methods·K L WhiteakerM Gopalakrishnan
Nov 5, 2002·Journal of Molecular Graphics & Modelling·Ulrike UhrigHorst Lemoine
Nov 6, 2012·Acta Pharmacologica Sinica·Hong-shuo Sun, Zhong-ping Feng
Nov 11, 1999·British Journal of Pharmacology·G C WellmanJ M Quayle
Feb 29, 2000·British Journal of Pharmacology·A R Rodrigues, I D Duarte
Aug 6, 2000·British Journal of Pharmacology·R EngbersenF G Russel

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
glycosylation

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.