A view on sphingolipids and disease

Chemistry and Physics of Lipids
Thomas Kolter

Abstract

Sphingolipid and glycosphingolipid levels and expression of sphingolipid metabolizing enzymes are altered in a variety of diseases or in response to drug treatment. Inherited defects of enzymes and other proteins required for the lysosomal degradation of these lipids lead to human sphingolipidoses. Also genetic defects that affect sphingolipid biosynthesis are known. Although the molecular details are often far from clear, (glyco)sphingolipids have been implicated to play a role in atherosclerosis, insulin resistance, cancer, and infections by pathogens. More general aspects of selected diseases are discussed.

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Citations

Nov 14, 2013·Chemistry and Physics of Lipids·David J MontefuscoYusuf A Hannun
Mar 25, 2014·Biochimica Et Biophysica Acta·Mary L Kraft, Haley A Klitzing
Oct 2, 2013·Oxidative Medicine and Cellular Longevity·Alexandra WoodacreRaffael Schaffrath
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Jan 1, 2012·Metabolites·Hany Farwanah, Thomas Kolter
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Aug 22, 2020·Journal of Lipid and Atherosclerosis·Anna Kovilakath, L Ashley Cowart
Nov 5, 2020·Critical Reviews in Analytical Chemistry·Jie Tang Han Han
Jan 21, 2021·Metabolites·Santosh LamichhaneMatej Orešič
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Sep 1, 2021·Biotechnology Advances·Zuzana MészárosKristýna Slámová

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