A virulent Wolbachia infection decreases the viability of the dengue vector Aedes aegypti during periods of embryonic quiescence.

PLoS Neglected Tropical Diseases
C J McMeniman, S L O'Neill

Abstract

A new approach for dengue control has been proposed that relies on life-shortening strains of the obligate intracellular bacterium Wolbachia pipientis to modify mosquito population age structure and reduce pathogen transmission. Previously we reported the stable transinfection of the major dengue vector Aedes aegypti with a life-shortening Wolbachia strain (wMelPop-CLA) from the vinegar fly Drosophila melanogaster. Here, we report a further characterization of the phenotypic effects of this virulent Wolbachia infection on several life-history traits of Ae. aegypti. Minor costs of wMelPop-CLA infection for pre-imaginal survivorship, development and adult size were found. However, we discovered that the wMelPop-CLA infection dramatically decreased the viability of desiccated Ae. aegypti eggs over time. Similarly, the reproductive fitness of wMelPop-CLA infected Ae. aegypti females declined with age. These results reveal a general pattern associated with wMelPop-CLA induced pathogenesis in this mosquito species, where host fitness costs increase during aging of both immature and adult life-history stages. In addition to influencing the invasion dynamics of this particular Wolbachia strain, we suggest that the negative impact of wM...Continue Reading

References

Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K T Min, S Benzer
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·E A McGrawS L O'Neill
Aug 7, 2004·Current Microbiology·Toon Ruang-areerateScott L O'Neill
Jul 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Helen J Wearing, Pejman Rohani
Aug 9, 2006·Journal of Medical Entomology·M Saiful Islam, Stephen L Dobson
Jun 7, 2007·Tropical Medicine & International Health : TM & IH·J FarrarUNKNOWN WHO/TDR Dengue Scientific Working Group
Mar 4, 2008·FEMS Microbiology Letters·Kirsten HilgenboeckerJohn H Werren
May 31, 2008·Advances in Experimental Medicine and Biology·Peter E CookScott L O'Neill
Nov 1, 2008·Science·Lauren M HedgesKaryn N Johnson
Sep 16, 2009·PLoS Neglected Tropical Diseases·Andrew P TurleyElizabeth A McGraw

❮ Previous
Next ❯

Citations

Sep 26, 2013·Future Microbiology·Steven P Sinkins
Oct 7, 2011·BMC Evolutionary Biology·Philip R CrainStephen L Dobson
Feb 13, 2013·Parasites & Vectors·Andrew P TurleyElizabeth A McGraw
Apr 14, 2012·Tropical Medicine and Health·Duane J Gubler
Apr 12, 2013·Proceedings. Biological Sciences·Ary A Hoffmann, Michael Turelli
Apr 17, 2012·Expert Opinion on Biological Therapy·Eric P Caragata, Thomas Walker
Aug 27, 2014·Ecological Applications : a Publication of the Ecological Society of America·Gordana RasićAry A Hoffmann
Dec 27, 2015·Asian Pacific Journal of Tropical Medicine·Uruj TahirBahar-E-Mustafa
Dec 18, 2013·Microbial Ecology·Eric P CaragataElizabeth A McGraw
May 7, 2011·EMBO Reports·Iñaki Iturbe-OrmaetxeScott L O' Neill
Oct 16, 2013·Journal of Evolutionary Biology·M SegoliJ A Rosenheim
Jan 19, 2016·Trends in Parasitology·Eric P CaragataLuciano A Moreira
Sep 15, 2015·Evolutionary Applications·Ary A HoffmannGordana Rašić
Nov 21, 2013·Acta Tropica·Kostas BourtzisJeremie R L Gilles
Aug 2, 2011·Current Opinion in Microbiology·Eric Marois
Mar 20, 2015·Science Translational Medicine·Neil M FergusonCameron P Simmons
Dec 17, 2014·PLoS Neglected Tropical Diseases·Michal SegoliScott A Ritchie
Feb 11, 2015·PLoS Biology·Ewa Chrostek, Luis Teixeira
Nov 8, 2012·PLoS Neglected Tropical Diseases·Andrew F van den HurkScott L O'Neill
Jul 24, 2015·PLoS Neglected Tropical Diseases·Scott A RitchieAry A Hoffmann
Aug 21, 2014·BMC Infectious Diseases·Stephan KarlGeorge J Milne
Jun 3, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Wan Fatma ZuharahNik Fadzly
Apr 16, 2014·The American Journal of Tropical Medicine and Hygiene·Perran A RossAry A Hoffmann
Dec 30, 2015·The American Journal of Tropical Medicine and Hygiene·Jason K AxfordAry A Hoffmann
May 17, 2017·Acta Tropica·Eunho SuhStephen L Dobson
Apr 14, 2017·The Journal of Infectious Diseases·Scott A Ritchie, Brian J Johnson
Feb 13, 2018·Journal of Mathematical Biology·Doris E Campo-DuarteMikhail Svinin
Dec 3, 2014·Applied and Environmental Microbiology·Irene L G Newton, Kathy B Sheehan
Jan 16, 2019·Tropical Medicine and Infectious Disease·Isabelle Jia-Hui FooPerran A Ross
Apr 20, 2019·PLoS Neglected Tropical Diseases·Perran A RossAry A Hoffmann
Feb 16, 2013·Nature Reviews. Microbiology·Elizabeth A McGraw, Scott L O'Neill

❮ Previous
Next ❯