A virus-like particle-based tetravalent vaccine for hand, foot, and mouth disease elicits broad and balanced protective immunity

Emerging Microbes & Infections
Wei ZhangZhong Huang

Abstract

Hand, foot, and mouth disease (HFMD) is an infectious disease that mainly affects infants and children, causing considerable morbidity and mortality worldwide. HFMD is commonly caused by enterovirus 71 (EV71) and coxsackieviruses A16 (CVA16), A6 (CVA6), and A10 (CVA10). Formalin-inactivated EV71 vaccines are currently available in China; however, these vaccines fail to confer cross-protection against infections by other HFMD-causing enteroviruses, highlighting the necessity of developing a multivalent HFMD vaccine. Our previous studies demonstrated that recombinant virus-like particles (VLP) of EV71, CVA16, and CVA6 are capable of inducing protective immunity against homologous virus challenges in mice. In this study, we generated CVA10-VLP using a baculovirus-insect cell expression system and then combined CVA10-VLP with EV71-VLP, CVA16-VLP, and CVA6-VLP to formulate a tetravalent VLP vaccine. Immunogenicity and protective efficacy of tetravalent VLP vaccine was compared with that of monovalent VLP vaccines. Mouse immunization studies revealed that the tetravalent vaccine elicited antigen-specific and long-lasting serum antibody responses comparable to those elicited by its corresponding monovalent vaccines. Moreover, tetraval...Continue Reading

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Citations

Sep 1, 2019·Expert Opinion on Drug Discovery·Ze Qin LimSylvie Alonso
Jan 22, 2020·Emerging Infectious Diseases·Lam Anh NguyetLe Van Tan
Dec 5, 2019·Therapeutic Advances in Vaccines and Immunotherapy·Hui Xuan Lim, Chit Laa Poh
Mar 16, 2019·International Journal of Molecular Sciences·Mohd Ishtiaq Anasir, Chit Laa Poh
Apr 5, 2020·Vaccines·Ciying QianNingshao Xia
Dec 19, 2019·Human Vaccines & Immunotherapeutics·Kelei LiZhenglun Liang
Sep 7, 2019·Antiviral Research·Minna M HankaniemiOlli H Laitinen
Mar 7, 2021·Vaccines·Mei-Ling LiGary Brewer
Mar 20, 2021·Emerging Microbes & Infections·Sha-Sha QianShuo Shen
May 1, 2021·International Journal of Molecular Sciences·Pharaoh Fellow MwaleYi-Yuan Yang
Aug 13, 2021·Expert Opinion on Drug Discovery·Chih-Yeu Fang, Chia-Chyi Liu
Nov 11, 2021·Human Vaccines & Immunotherapeutics·Yaqian HuoZhenglun Liang

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Datasets Mentioned

BETA
KF682362

Methods Mentioned

BETA
reverse transcription PCR
protein assay

Software Mentioned

GraphPad Prism

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