A vision of cell death: insights into immune privilege

Immunological Reviews
T A Ferguson, T S Griffith

Abstract

Immune privilege is a term applied to several organs that have a unique relationship with the immune response. These sites prohibit the spread of inflammation since even minor episodes can threaten organ integrity and function. The most prominent examples of these are the eye, brain and reproductive organs where immune responses either do not proceed, or proceed in a manner different from other areas. Once thought to be a passive process relying on physical barriers, immune privilege can now be viewed as an active process that utilizes multiple mechanisms to maintain organ function. Recently there has been a renewed interest in immune privilege when it was shown that two privileged sites (the eye and testes) constitutively express FasL, which functions by killing lymphoid cells that invade these areas. Here we will examine the role of FasL in immune privilege and discuss how this molecule interacts with other elements of the inflammatory response to maintain organ integrity in the face of potentially damaging immune reactions.

References

Aug 1, 1992·Journal of Neuroimmunology·J W StreileinS W Cousins
May 1, 1991·The Journal of Investigative Dermatology·J GutwaldC Sorg
Apr 1, 1991·Current Eye Research·P HooperT A Ferguson
Jul 1, 1990·Immunology Today·H G Ljunggren, K Kärre
Aug 15, 1989·American Journal of Ophthalmology·S E BradyP R Laibson
Nov 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T A FergusonH J Kaplan
Nov 1, 1988·Immunology Today·I R Cohen, H L Weiner
Jan 1, 1984·Annual Review of Immunology·M E Dorf, B Benacerraf
May 1, 1981·The Journal of Experimental Medicine·J W Streilein, J Y Niederkorn
Nov 17, 1995·Science·T S GriffithT A Ferguson
Oct 1, 1994·European Journal of Immunology·M GrellP Scheurich
Mar 10, 1995·Science·S Nagata, P Golstein
Jan 1, 1995·Immunology Today·S Nagata, T Suda
Oct 19, 1995·Nature·D BellgrauR C Duke
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
May 1, 1994·The Journal of Experimental Medicine·T A FergusonT S Griffith
Mar 1, 1996·Nature Medicine·M TanakaS Nagata

❮ Previous
Next ❯

Citations

Sep 6, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fabrizio VianelloMark C Poznansky
Sep 5, 2002·Mathematical Biosciences·Steven D WebbReginald G Fish
Mar 9, 2000·Journal of Reproductive Immunology·A Hammer, G Dohr
Jun 1, 2002·Human Immunology·J Wayne StreileinTakeshi Kezuka
Oct 2, 1998·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Mathé
Feb 19, 2000·Current Opinion in Genetics & Development·M J Pinkoski, D R Green
Jan 1, 2003·Transplant Immunology·Sandrine CappellessoYvon Lebranchu
May 14, 2003·Progress in Retinal and Eye Research·Chad E N Reiter, Thomas W Gardner
Aug 13, 1999·Breast Cancer Research and Treatment·L S GutierrezG Mor
Feb 17, 2006·Nature Immunology·John Trowsdale, Alexander G Betz
Mar 29, 2000·Scandinavian Journal of Immunology·E SunW Gao
Sep 9, 1998·The Journal of Experimental Medicine·Y GaoT A Ferguson
Nov 2, 1999·The Journal of Experimental Medicine·S Hong, L Van Kaer
Jun 10, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Nancy Gordon, Eugenie S Kleinerman
Dec 28, 1999·Transplantation·J Y NiederkornI Stroynowski
Apr 16, 2002·Infection and Immunity·Nicola L JonesPhilip M Sherman
Aug 20, 2004·The British Journal of Ophthalmology·J PlskovaJ V Forrester
Mar 10, 2000·Pediatric Research·D R BalkundiS Sharma
Jul 5, 2001·Journal of Neuroimmunology·L P McCluskey, L A Lampson
Dec 2, 1999·Journal of Neuroimmunology·C J Harling-BergP M Knopf
Feb 26, 2008·Seminars in Immunopathology·Thomas A Ferguson, Rajendra S Apte
Apr 5, 2011·Seminars in Immunopathology·Suzanne Kadereit, Alan Trounson
Jan 19, 2016·Scientific Reports·Justin RustenhovenMike Dragunow
Oct 31, 2012·Progress in Retinal and Eye Research·Manabu MochizukiKoju Kamoi
Oct 22, 2011·Animal Reproduction Science·Fan JiangFengLiu Ben
Sep 29, 2006·Journal of Anatomy·James W Godwin, Jeremy P Brockes
Sep 16, 2006·Immunological Reviews·Thomas A Ferguson, Thomas S Griffith
Apr 15, 2011·Immunological Reviews·Thomas A FergusonDouglas R Green
Sep 12, 2013·Mediators of Inflammation·Ulrike GimsaMonika C Brunner-Weinzierl
May 20, 2015·Trends in Immunology·Victor L Perez, Rachel R Caspi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.