A Voxel-Based Magnetic Resonance Imaging Morphometric Study of Cerebral and Cerebellar Gray Matter in Patients Under 65 Years with Essential Tremor

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Hongmei CaoXiaobo Yang

Abstract

BACKGROUND The aim of this study was to compare the morphological changes in cerebral and cerebellar gray matter in patients with essential tremor under 60-years-of-age, with age-matched and gender-matched normal healthy volunteer control subjects, using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM) analysis. MATERIAL AND METHODS A retrospective, controlled, comparative clinical study included 17 patients with essential tremor, <60 years-of-age, and 17 age-matched and gender-matched healthy volunteer control subjects, recruited between June 2010-July 2012. MRI and VBM analysis were used to compare cerebral and cerebellar gray matter density between groups. The Washington Heights-Inwood Genetic Study of Essential Tremor (WHIGET) rating scale was used to assess tremor severity in the patient group. Clinical and demographic characteristics were recorded for all study participants. RESULTS MRI and VBM analysis showed significant bilateral expansion of the cerebellum, occipital fusiform cortices, right inferior temporal gyrus, and precentral lobes in patients with essential tremor (P<0.005); reduction in gray matter was found in the left parietal lobe. The region of interest (ROI) analysis showed vol...Continue Reading

Citations

Apr 13, 2019·Acta Neurologica Scandinavica·Ioannis MavroudisDimitrios Kazis
May 30, 2019·European Radiology·Sara PietracupaPatrizia Pantano
May 23, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rong LuoLing Chen
Apr 4, 2021·Medicina·Ioannis MavroudisDimitrios Kazis
Jul 6, 2021·Frontiers in Neurology·Florian Holtbernd, N Jon Shah
Dec 31, 2019·Clinical Parkinsonism & Related Disorders·María Carolina Sepúlveda Soto, Alfonso Fasano

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

Non
FSL
MATLAB
SPSS
FMRIB
FSLView
- Linear Image Registration Tool ( FNIRT )
Linear Image Registration Tool ( FLIRT )
VBM
FAST4

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