A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder

PloS One
Xinhu JinJinyao Yi

Abstract

Increasing evidence has documented subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). However, results of magnetic resonance imaging volumetry in patients with BPD are inconsistent. In addition, few researchers using voxel-based morphometry (VBM) have focused on attachment and childhood trauma in BPD. This preliminary study was performed to investigate structural brain changes and their relationships to attachment and childhood trauma in a homogenous sample of young adults with BPD. We examined 34 young adults with BPD and 34 healthy controls (HCs) to assess regionally specific differences in gray matter volume (GMV) and gray matter concentration (GMC). Multiple regressions between brain volumes measured by VBM and attachment style questionnaire (ASQ) and childhood trauma questionnaire (CTQ) scores were performed. Compared with HCs, subjects with BPD showed significant bilateral increases in GMV in the middle cingulate cortex (MCC)/posterior cingulate cortex (PCC)/precuneus. GMC did not differ significantly between groups. In multiple regression models, ASQ insecure attachment scores were correlated negatively with GMV in the precuneus/MCC and middle occipital gyrus in HCs, H...Continue Reading

References

Oct 1, 1983·Journal of Personality Assessment·N V RamanaiahT Schill
Aug 1, 1997·The American Journal of Psychiatry·M C ZanariniF R Frankenburg
Apr 26, 2000·Anesthesiology·M E FaymonvilleP Maquet
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Nov 4, 2000·The American Journal of Psychiatry·D SimeonM S Buchsbaum
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Nov 15, 2001·NeuroImage·J Ashburner, K J Friston
Jun 14, 2002·Biological Psychiatry·Andrew E SkodolLarry J Siever
Jul 26, 2002·Journal of Personality Disorders·Paul H SoloffThomas M Kelly
Mar 14, 2003·Neuroreport·Richard J MaddockAmy S Garrett
Jul 5, 2003·Journal of Psychiatric Research·F D JuenglingK Lieb
Dec 6, 2003·The European Journal of Neuroscience·Brent A VogtStuart W G Derbyshire
Feb 24, 2004·Annual Review of Physiology·Nikos K Logothetis, Brian A Wandell
Mar 10, 2004·NeuroImage·Andreas Bartels, Semir Zeki
Jun 19, 2004·Harvard Review of Psychiatry·Hans R AgrawalKarlen Lyons-Ruth
Aug 18, 2004·Biological Psychiatry·Ellen LeibenluftJames V Haxby
Jul 5, 2005·Nature Reviews. Neuroscience·Brent A Vogt
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
May 2, 2006·The American Journal of Psychiatry·Mary C ZanariniKenneth R Silk
Dec 22, 2006·Psychiatry Research·Uwe HerwigSusanne Erk
May 18, 2007·Attachment & Human Development·Heidi Neufeld BaileyDavid R Pederson
Sep 1, 2007·NeuroImage·John Ashburner
Sep 11, 2007·Journal of Psychiatric Research·Michael J MinzenbergLarry J Siever
Oct 1, 2008·Neuroscience and Biobehavioral Reviews·Samantha J BroydEdmund J S Sonuga-Barke
Jan 28, 2009·Criminal Behaviour and Mental Health : CBMH·Birgit A VöllmMairead C Dolan
Jan 5, 2011·Lancet·Falk LeichsenringFrank Leweke
Apr 7, 2011·Social Cognitive and Affective Neuroscience·C Nathan DeWallNaomi I Eisenberger
May 27, 2011·The New England Journal of Medicine·John G Gunderson
Feb 18, 2012·Journal of Psychiatric Research·Paul H SoloffVaibhav A Diwadkar
Apr 17, 2012·Depression and Anxiety·Yi JinyaoYao Shuqiao
May 29, 2012·Archives of General Psychiatry·Rosemarie C KluetschRuth A Lanius
Aug 23, 2012·Journal of Psychiatry & Neuroscience : JPN·Andrea KuhlmannSabine C Herpertz

❮ Previous
Next ❯

Software Mentioned

SPM
DARTEL
Statistical Parametric Mapping ( SPM
DARTEL Algebra
Statistical Package for Social Sciences
VBM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.