A Voxel-Wise Meta-Analysis of Gray Matter Abnormalities in Essential Tremor

Frontiers in Neurology
Qing HanHuiFang Shang

Abstract

Objective: To identify the consistent gray matter (GM) volume changes from the whole brain voxel-based morphometry (VBM) studies on essential tremor (ET). Methods: The whole brain VBM studies comparing ET patients and healthy controls (HCs) were systematically searched in the PubMed, Embase and Web of Science from January 2000 to December 2017. Coordinates with significant differences in regional GM volume between ET patients and HCs were extracted from included studies and the meta-analysis was performed using effect size-based signed differential mapping (ES-SDM). Results: A total of 10 studies with 241 ET patients and 213 HCs were included in the meta-analysis. The consistent GM volume reduction was detected in the left precuneus extending to the left posterior cingulate gyrus. The subgroup meta-analysis which included studies performed on a 3.0 T scanner revealed significant GM volume increases in the bilateral frontal lobes, bilateral temporal lobes, left insula, left striatum and left pons, but obvious publication biases of these findings were detected through funnel plots and Egger's tests. Conclusions: The consistent result of our meta-analysis showed a structural damage in the left precuneus extending to the left poste...Continue Reading

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Citations

Apr 13, 2019·Acta Neurologica Scandinavica·Ioannis MavroudisDimitrios Kazis
May 30, 2019·European Radiology·Sara PietracupaPatrizia Pantano
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Mar 16, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sara PietracupaPatrizia Pantano
Apr 4, 2021·Medicina·Ioannis MavroudisDimitrios Kazis
Jan 25, 2022·Experimental and Therapeutic Medicine·Ioannis MavroudisStavros J Baloyannis

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