A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin

Phytotherapy Research : PTR
Thomas MammoneRonald W Pero

Abstract

Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties. These two biological mechanisms are key molecular targets to develop treatments that protect skin exposed to ultraviolet light from the sun. Because C-Med-100, a Cat's Claw water extract, is the only documented natural source of components that can up-regulate simultaneously both DNA repair and antiinflammation, its ability to modulate DNA repair in human skin organ cultures was undertaken. For this purpose skin cultures were treated with or without 5 mg/mL C-Med-100, irradiated with 0-100 mJ/cm2 UVB, and microscopically analysed for necrosis as well as the level of pyrimidine dimers using immunofluorescent TT-dimer antibody staining. The data clearly demonstrated that co-incubation with C-Med-100 reduced skin cell death from UV exposure, and this protection was accounted for by a concomitant increase in DNA repair. Based on these results, it was concluded that C-Med-100 was a natural plant extract worthy of further consideration as a sunscreen product.

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Citations

Jul 20, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Maria do Carmo Santos AraújoMaria Rosa Chitolina Schetinger
Jul 21, 2011·Journal of Ethnopharmacology·Iria FariasMaria Rosa Chitolina Schetinger
Jun 12, 2012·Journal of Ethnopharmacology·Milena BorsBożena Bukowska
Jun 9, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Lidia Yileng TayFabio Andre Dos Santos
Oct 11, 2008·Phytotherapy Research : PTR·Ronald W PeroTomas Leanderson
Jun 20, 2015·Acta Crystallographica. Section E, Crystallographic Communications·Man ZhangDa-Zhi Li
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali ZariRobert Lafrenie

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