A water-soluble polycarbonate with dimethylamino pendant groups prepared by enzyme-catalyzed ring-opening polymerization

Macromolecular Rapid Communications
Xiaojin ZhangRen-Xi Zhuo

Abstract

A water-soluble polycarbonate with dimethylamino pendant groups, poly(2-dimethylaminotrimethylene carbonate) (PDMATC), is synthesized and characterized. First, the six-membered carbonate monomer, 2-dimethylaminotrimethylene carbonate (DMATC), is prepared via the cyclization reaction of 2-(dimethylamino)propane-1,3-diol with triphosgene in the presence of triethylamine. Although the attempted ring-opening polymerization (ROP) of DMATC with Sn(Oct)(2) as a catalyst fails, the ROP of DMATC is successfully carried out with Novozym-435 as a catalyst to give water-soluble aliphatic polycarbonate PDMATC with low cytotoxicity and good degradability.

References

May 11, 2007·Journal of the American Chemical Society·Andrew P GoodwinJean M J Fréchet
Jul 14, 2007·Angewandte Chemie·Meng ShiMolly S Shoichet
Sep 13, 2007·Macromolecular Bioscience·Trishul Artham, Mukesh Doble
Nov 13, 2007·Biomacromolecules·Fredrik NederbergJames L Hedrick
May 28, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei Yang Seow, Yi Yan Yang
Jun 16, 2009·Angewandte Chemie·Olivier CoulembierJames L Hedrick
Oct 29, 2009·Journal of the American Chemical Society·Christina B CooleyPaul A Wender
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter N ZawanehDavid Putnam
May 19, 2011·Macromolecular Rapid Communications·Jeremy P K TanJames L Hedrick

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Citations

May 27, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei ChenZhiyuan Zhong
Jul 6, 2014·Journal of Applied Polymer Science·Jianwen XuJie Song
Nov 3, 2016·Macromolecular Rapid Communications·Elyse ChampagneXiao-Xia Zhu
Sep 26, 2019·Macromolecular Rapid Communications·Jingjiang SunDirk Kuckling
Jul 8, 2021·Macromolecular Bioscience·Víctor HevillaMarta Fernández-García

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