A-waves in Guillain-Barré syndrome: correlation with electrophysiological subtypes and antiganglioside antibodies

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Shingo KawakamiTeruo Shimizu

Abstract

To investigate the relationship of A-waves with conventional electrophysiological subtypes of Guillain-Barré syndrome (GBS), as well as with anti-ganglioside antibodies. The subjects consisted of 30GBS patients who were classified into acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy, and unclassified based on the results of nerve conduction studies. "Abundant A-waves" were defined for the upper-limb nerves (median and ulnar nerves) using receiver-operator characteristic curves. The presence or absence of IgG anti-ganglioside antibodies was also noted. Abundant A-waves at weeks 3-6 from onset were observed in 64% of the 14 AIDP patients and 0% of 16 non-AIDP patients, and in 60% of 15 antibody-negative patients and 0% of 15 antibody-positive patients. In the earlier period, this relationship was less clear. The correlation between the conventional electrophysiological subtypes and antibodies was present, but was much weaker. Abundant A-waves in GBS after the acute phase were strongly associated with demyelination that was not mediated by antiganglioside antibodies, possibly through the mechanism of proximal re-excitation induced by electrical inhomogeneities due to segmental demyelin...Continue Reading

References

Mar 1, 1984·Brain : a Journal of Neurology·W F Brown, T E Feasby
Feb 1, 1994·Annals of Neurology·A J KornbergZ Jiang
Dec 1, 1996·Electroencephalography and Clinical Neurophysiology·C BischoffL Puksa
Mar 23, 1999·Muscle & Nerve·M E KornhuberB Conrad
Dec 28, 1999·Brain : a Journal of Neurology·K KaidaI Kanazawa
Jul 7, 2000·Muscle & Nerve·J Rowin, M N Meriggioli
May 20, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·Robert D M Hadden, Richard A C Hughes
Oct 23, 2003·Muscle & Nerve·Leena PuksaBjörn Falck
Sep 8, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Steve VucicDidier Cros
Sep 25, 2004·Annals of Neurology·Ken-ichi KaidaSusumu Kusunoki
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Keiichiro SusukiNobuhiro Yuki
Sep 22, 2010·Brain : a Journal of Neurology·Norito KokubunNobuhiro Yuki

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Citations

Apr 11, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Akiko KadoyaMasahiro Sonoo
Sep 13, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Elena GallardoJosé Berciano
May 31, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Sindhuja LakshminarasimhanLakshminarasimhan Ranganathan
Apr 30, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Reda Badry

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