PMID: 2116997Aug 15, 1990Paper

A weakly tumorigenic phenotype with high MHC class-I expression is associated with high metastatic potential after surgical removal of the primary murine fibrosarcoma

International Journal of Cancer. Journal International Du Cancer
M PérezFederico Garrido

Abstract

We have examined the metastatic capacity of different clones of a chemically induced fibrosarcoma GR9. These clones have previously been characterized for their H-2 class-I and class-II phenotype, NK sensitivity and local tumor growth. Our present data show that clones which express low amounts of H-2 class-I antigens are poorly metastatic in a post-surgical spontaneous metastasis assay, while those expressing high levels of class-I antigens possess a high metastatic capacity. These results correlate inversely with local growth patterns of the clones. High metastatic capacity was associated with resistance to NK cells. In an experimental metastasis assay, based on intravenous administration of in vitro carried GR9 clones to syngeneic BALB/c mice, an opposite result to the post-surgical assay was obtained. Gamma-IFN treatment of B9 clones (H-2-deficient) enhanced H-2 class-I expression and diminished experimentally induced metastases. Metastatic colonies, from the spontaneous metastasis assay, obtained from different organs, showed changes in the ratio H-2K/H-2D. There was a tendency for down-regulation of the expression of H-2K molecules in H-2-positive clones and for up-regulation of H-2D expression in H-2-negative clones.

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Citations

Jan 10, 2001·International Journal of Cancer. Journal International Du Cancer·A Garcia-LoraF Garrido
Jul 14, 2010·Cancer Immunology, Immunotherapy : CII·Federico GarridoAngel M García-Lora
May 10, 2011·Cancer Immunology, Immunotherapy : CII·Cristina GarridoFederico Garrido
Jul 27, 2012·Cancer Immunology, Immunotherapy : CII·Monica BernalFederico Garrido
Apr 28, 2000·International Journal of Clinical & Laboratory Research·S PedrinaciF Garrido
May 17, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bor-Ching SheuSu-Ming Hsu
Dec 5, 2014·International Journal of Cancer. Journal International Du Cancer·Federico GarridoAngel M Garcia-Lora
Mar 28, 2012·The Journal of Pathology·Irene RomeroAngel M Garcia-Lora
Apr 22, 2003·Journal of Cellular Physiology·Angel Garcia-LoraFederico Garrido
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Angel Garcia-LoraFederico Garrido
Dec 14, 2011·Journal of Veterinary Internal Medicine·Wallace B Morrison
Dec 2, 1991·International Journal of Cancer. Journal International Du Cancer·J J GaforioF Garrido
Jan 1, 1991·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·I AlgarraF Garrido
May 28, 1993·International Journal of Cancer. Journal International Du Cancer·I AlgarraF Garrido
Aug 19, 1992·International Journal of Cancer. Journal International Du Cancer·M J MialdeaF Garrido
Nov 21, 2014·Cancer Research·Irene RomeroAngel M Garcia-Lora
Feb 18, 2014·Cancer Research·Irene RomeroAngel M Garcia-Lora
Mar 20, 2021·Frontiers in Cell and Developmental Biology·Alberto Hernández-BarrancoHéctor Peinado
Apr 17, 2021·Cancer Metastasis Reviews·Ignacio AlgarraAngel M Garcia-Lora

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