A Weibull-PBPK model for assessing risk of arsenic-induced skin lesions in children

The Science of the Total Environment
Chung-Min LiaoSzu-Chieh Chen

Abstract

Chronic arsenic exposure and skin lesions (keratosis and hyperpigmentation) are inextricably linked. This paper was to quantify the children skin lesions risks and to further recommend safe drinking water arsenic standard based on reported arsenic epidemiological data. We linked the Weibull dose-response function and a physiologically based pharmacokinetic (PBPK) model to estimate safe drinking water arsenic concentrations and to perform the risk characterization. We calculated odds ratios (ORs) to assess the relative magnitude of the effect of the arsenic exposure on the likelihood of the prevalence of children skin lesions by calculating proposed Weibull-based prevalence ratios of exposed to control groups associated with the age group-specific PBPK model predicted dimethylarsinite (MMA(III)) levels in urine. Positive relationships between arsenic exposures and cumulative prevalence ratios of skin lesions were found using Weibull dose-response model (r2=0.91-0.96). We reported that the safe drinking water arsenic standards were recommended to be 2.2 and 1 microg/L for male and 6 and 2.8 microg/L for female in 0-6 and 7-18 years age groups, respectively, based on hyperpigmentation with an excess risk of 10(-3) for a 75 years l...Continue Reading

References

Dec 1, 1985·Toxicology and Industrial Health·A H Smith, D S Sharp
Dec 5, 1998·International Journal of Epidemiology·D N Guha MazumderA H Smith
May 26, 1999·Regulatory Toxicology and Pharmacology : RTP·D Yu
May 16, 2000·Environmental Health Perspectives·U K ChowdhuryD Chakraborti
Jul 21, 2000·Environmental Health Perspectives·K H MoralesC J Chen
Dec 28, 2000·Journal of Occupational and Environmental Medicine·H AhsanJ Graziano
Sep 8, 2001·Journal of Environmental Health
Dec 6, 2001·Journal of Toxicology and Environmental Health. Part a·S HaddadK Krishnan
Apr 3, 2002·Industrial Health·Derek Richard SmithHamm-Ming Sheu
Mar 15, 2003·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Uttam Kumar ChowdhuryDipankar Chakraborti
Mar 29, 2003·Journal of Occupational and Environmental Medicine·Yen-Ching ChenDavid C Christiani
Apr 26, 2003·Journal of Toxicology and Environmental Health. Part a·Karine PriceKannan Krishnan
Dec 12, 2003·Journal of Toxicology and Environmental Health. Part a·P Robinan GentryHarvey J Clewell
Jun 22, 2005·Toxicology and Applied Pharmacology·Chien-Jen ChenMeei-Maan Wu
Nov 5, 2005·American Journal of Epidemiology·Ana Navas-AcienEliseo Guallar
Feb 16, 2006·Journal of Epidemiology and Community Health·Mahfuzar RahmanLars Ake Persson
Jun 14, 2006·Regulatory Toxicology and Pharmacology : RTP·R L KodellJ F Young
Jul 13, 2006·Environmental Health Perspectives·Steven H LammManning Feinleib

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Citations

May 9, 2014·Environmental Geochemistry and Health·Min-Pei LingChung-Min Liao
Jul 14, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael F HughesDavid J Thomas
Nov 13, 2008·Environmental Geochemistry and Health·Andrew Hursthouse, George Kowalczyk
Jun 16, 2010·Journal of Hazardous Materials·Bo-Ching ChenChung-Min Liao

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