A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma

Scientific Reports
Weijian ZhangGuowang Xu

Abstract

Dynamic metabolomics studies can provide a systematic view of the metabolic trajectory during disease development and drug treatment and reveal the nature of biological processes at metabolic level. To extract important information in a systematic time dimension rather than at isolated time points, a weighted method based on the means and variations along the time points was proposed and first applied to previously published rat model data. The method was subsequently extended and applied to prospective metabolomics data analysis of hepatocellular carcinoma (HCC). Permutation was employed for noise filtering and false discovery rate (FDR) was used for parameter optimization during the feature selection. Long-term elevated serum bile acids were identified as risk factors for HCC development.

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Citations

Sep 12, 2016·Analytical and Bioanalytical Chemistry·Zhicheng LiuGuowang Xu
Aug 11, 2015·Diseases·Mukesh Verma, Hirendra Nath Banerjee
Jul 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Elisa ManieriGuadalupe Sabio
Mar 28, 2021·British Journal of Cancer·Yuanjie PangLiming Li
Apr 12, 2017·Journal of Medicinal Chemistry·Ying-Ming ZhangYu Liu

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Methods Mentioned

BETA
PCA

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DA
PLS
SAM

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