Abstract
To evaluate the association of genetic risk scores (GRS) of LDLR, APOB and proprotein convertase subtilisin-kexin type 9 (PCSK9) SNP and plasma LDL concentrations and to identify lifestyle interactions with the GRS in Korean middle-aged adults. Korean genome and epidemiology study (KoGES) was conducted to determine genetic variants and lifestyle factors, including nutrient intakes, in a retrospective hospital-based city cohort conducted by the Korean Center for Disease and Control during 2004-2013. Hospitals in Korea. Adults aged 40-77 years (n 28 445) without serious diseases. Subjects with the major alleles (risk allele) of LDLR rs1433099 and rs11557092, APOB rs13306194 and PCSK9 rs11583723 had higher plasma LDL concentration by 1·20-folds than those with the minor alleles. Subjects with High-GRS (major alleles) of the four SNP had higher adjusted OR for plasma total and LDL-cholesterol and TAG concentrations by 1·24-, 1·203- and 1·167-folds, respectively, but not HDL-cholesterol, than those with Low-GRS. Western-style flour-rich dietary patterns, but not balanced Korean-style and rice-based dietary patterns, had interactions with GRS to increase plasma LDL concentrations. Daily energy intake also interacted with GRS. In the ...Continue Reading
References
May 1, 1994·The Journal of Clinical Investigation·S IshibashiD K Burns
Feb 12, 1998·BMJ : British Medical Journal·M EggerA N Phillips
Mar 6, 2002·European Journal of Nutrition·G AssetJ Dallongeville
Apr 4, 2006·Journal of the American College of Nutrition·Yunsheng MaIra S Ockene
May 16, 2006·Journal of Endocrinological Investigation·S LimN H Cho
Feb 15, 2007·European Journal of Clinical Nutrition·Y AhnD H Kim
Jan 11, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Y Song, H Joung
Jun 6, 2013·Menopause : the Journal of the North American Menopause Society·Liping WuZhong He
Dec 4, 2014·Nutrition·Sunmin ParkByung-Kook Lee
Nov 26, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sunmin ParkByung-Kook Lee
Apr 17, 2016·International Journal of Epidemiology·Yeonjung KimUNKNOWN KoGES group
May 24, 2016·Nutrition & Metabolism·Sunmin ParkYong Hyun Lee
Nov 9, 2016·International Journal of Food Sciences and Nutrition·Sunmin ParkByung-Kook Lee
Mar 23, 2017·BMC Public Health·Gwang-Sil KimJi-Hyuck Rhee
Jun 5, 2017·Lipids in Health and Disease·C S PaththinigeVhw Dissanayake
Sep 2, 2017·Circulation Research·Darryl P LeongSalim Yusuf
Feb 1, 2018·Metabolism: Clinical and Experimental·Kevin D NiswenderHeidi J Silver
Apr 21, 2018·Nutrition Research·Kyung-Won HongSunmin Park
May 21, 2018·European Journal of Nutrition·Sunmin ParkSuna Kang
Oct 3, 2018·Atherosclerosis·Antonio J Vallejo-Vaz, Kausik K Ray
Nov 22, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M I ZafarL L Chen
Feb 19, 2019·NPJ Genomic Medicine·Maya S SafarovaIftikhar J Kullo
Jun 23, 2019·Current Cardiology Reports·Ricardo SteinFernando Scolari
Jul 16, 2019·Nutrition Journal·Seong-Ah KimSangah Shin
Sep 7, 2019·Atherosclerosis·Mika HoriMariko Harada-Shiba
Sep 14, 2019·Atherosclerosis·Rosa M Sánchez-HernándezGiuliana Fortunato
Citations
Feb 7, 2021·Nutrients·Xuangao WuSunmin Park
Apr 4, 2021·Cancers·Sang Shin SongSunmin Park
May 18, 2021·Appetite·Shina LeowBen Jackson
Aug 28, 2021·Nutrients·Sunmin Park, Suna Kang