A White Matter Connection of Schizophrenia and Alzheimer's Disease.

Schizophrenia Bulletin
Peter KochunovL Elliot Hong

Abstract

Schizophrenia (SZ) is a severe psychiatric illness associated with an elevated risk for developing Alzheimer's disease (AD). Both SZ and AD have white matter abnormalities and cognitive deficits as core disease features. We hypothesized that aging in SZ patients may be associated with the development of cerebral white matter deficit patterns similar to those observed in AD. We identified and replicated aging-related increases in the similarity between white matter deficit patterns in patients with SZ and AD. The white matter "regional vulnerability index" (RVI) for AD was significantly higher in SZ patients compared with healthy controls in both the independent discovery (Cohen's d = 0.44, P = 1·10-5, N = 173 patients/230 control) and replication (Cohen's d = 0.78, P = 9·10-7, N = 122 patients/64 controls) samples. The degree of overlap with the AD deficit pattern was significantly correlated with age in patients (r = .21 and .29, P < .01 in discovery and replication cohorts, respectively) but not in controls. Elevated RVI-AD was significantly associated with cognitive measures in both SZ and AD. Disease and cognitive specificities were also tested in patients with mild cognitive impairment and showed intermediate overlap. SZ a...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Aug 27, 1998·Schizophrenia Bulletin·J L KnollB McDermott
Nov 13, 1998·The American Journal of Psychiatry·A J DworkI Prohovnik
Dec 19, 1998·Social Psychiatry and Psychiatric Epidemiology·J Van OsR M Murray
Sep 25, 1999·Psychiatry and Clinical Neurosciences· AdityanjeeV R Vieweg
Oct 18, 2000·Biological Psychology·T A Salthouse
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Mar 21, 2003·History of Psychiatry·R M Ion, M D Beer
Aug 21, 2004·International Psychogeriatrics·Maddalena Bruscoli, Simon Lovestone
Jan 25, 2005·Nature Neuroscience·P Thomas SchoenemannL Daniel Glotzer
Nov 12, 2005·Neuropathology and Applied Neurobiology·K ChalmersS Love
Sep 12, 2006·Journal of the International Neuropsychological Society : JINS·Elizabeth W TwamleyMark W Bondi
Oct 18, 2008·Neurobiology of Aging·George BartzokisJim Mintz
Sep 25, 2009·Neurobiology of Aging·George Bartzokis
Feb 18, 2010·The American Journal of Psychiatry·Rocío Pérez-IglesiasBenedicto Crespo-Facorro
Jun 4, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lars PenkeIan J Deary
Apr 21, 2011·Schizophrenia Bulletin·Dilip V JesteBarton W Palmer
Jun 8, 2011·Archives of General Psychiatry·Patrick J BrownUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 5, 2012·Schizophrenia Bulletin·Francesco CarlettiPhilip K McGuire
Apr 23, 2013·Lancet Neurology·Joanna M WardlawMartin Dichgans
Jul 11, 2013·The Journal of Comparative Neurology·Ana SolodkinJames Mastrianni
Aug 9, 2013·JAMA Psychiatry·René S Kahn, Richard S E Keefe
Nov 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·David C GlahnJohn Blangero
Jul 25, 2014·Brain : a Journal of Neurology·Nicolas A CrossleyEdward T Bullmore
Jul 30, 2014·Psychological Medicine·H KarbasforoushanN D Woodward
Apr 1, 2015·Molecular Psychiatry·P FalkaiA Schmitt
Jul 6, 2015·Molecular Neurobiology·Cátia JanotaMaria Alexandra Brito
Jul 22, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W Weiner, Dallas P Veitch
Oct 8, 2015·JAMA Psychiatry·Anette Riisgaard RibeMogens Vestergaard
Oct 29, 2015·JAMA Psychiatry·Mark OlfsonT Scott Stroup
Nov 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Peter KochunovL Elliot Hong
Jan 10, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alan S LewisMichael H Bloch
Jul 18, 2017·Frontiers in Molecular Neuroscience·Divya RajErik Boddeke

❮ Previous
Next ❯

Citations

Jun 10, 2021·Journal of Holistic Nursing : Official Journal of the American Holistic Nurses' Association·Verónica G Walker, Elizabeth K Walker

❮ Previous
Next ❯

Software Mentioned

ENIGMA

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.