Apr 18, 2020

α-Synuclein perturbs in vivo neural activity following seeding in the olfactory bulb

BioRxiv : the Preprint Server for Biology
A. S. KulkarniDaniel W. Wesson


Parkinson's disease (PD) neuropathology is characterized by intraneuronal protein aggregates composed of misfolded -Synuclein (-Syn), as well as degeneration of substantia nigra dopamine neurons. Deficits in olfactory perception and aggregation of -Syn in the olfactory bulb (OB) are observed during early stages of PD, and have been associated with the PD prodrome, before onset of the classic motor deficits. -Syn fibrils injected into the OB of mice cause progressive propagation of -Syn pathology throughout the olfactory system and are coupled to olfactory perceptual deficits. We hypothesized that accumulation of pathogenic -Syn in the OB impairs neural activity in the olfactory system. To address this, we monitored spontaneous and odor-evoked local field potential dynamics in awake wild type mice simultaneously in the OB and piriform cortex (PCX) one, two, and three months following injection of pathogenic preformed -Syn fibrils in the OB. We detected -Syn pathology in both the OB and PCX. We also observed that the presence of -Syn pathology, triggered by -Syn fibril injection, influenced certain oscillatory spectral bands in these regions. These changes in neural activity occurred with region specificity, and in some cases tra...Continue Reading

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Mentioned in this Paper

Biological Markers
Real-Time Polymerase Chain Reaction
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Whole Blood
Muscle Cells
Transcription, Genetic
Cessation of Life
Candidate Disease Gene
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