PMID: 7581368Aug 1, 1995Paper

A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin

Human Molecular Genetics
L HansenO Pedersen

Abstract

The regulatory G-subunit of the glycogen-associated form of protein phosphatase 1 (PP1) plays a crucial part in muscle tissue glycogen synthesis and breakdown. As impaired insulin stimulated glycogen synthesis in peripheral tissues is considered to be a pathogenic factor in subsets of non-insulin-dependent diabetes mellitus (NIDDM) and obesity, the G-subunit of PP1 should be viewed as a candidate gene for inherited insulin resistance. When applying heteroduplex formation analysis and nucleotide sequencing of PP1G-subunit cDNA from 30 insulin resistant white NIDDM patients two cases were identified as heterozygous carriers of an Asp905 --> Tyr substitution. The carrier prevalence of the PP1G-subunit variant was 18% in 150 healthy subjects and 13% in 313 NIDDM subjects (chi 2 = 1.94, p = 0.16). Twenty-seven healthy subjects volunteered for a 4 h euglycaemic, hyperinsulinaemic clamp in combination with indirect calorimetry in order to elucidate the potential impact of the Tyr905 substitution on the whole body glucose metabolism. Interestingly, the Tyr905 variant was associated with altered routing of glucose: a decreased insulin stimulated non-oxidative glucose metabolism of peripheral tissues (glycogen synthesis) (p < 0.04) and a...Continue Reading

Citations

Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Pérez-MartinJ Mercier
Aug 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·D LiolitsaS Lovestone
Jan 1, 1997·Annual Review of Genetics·E HeardP Avner
May 3, 2003·The Journal of Clinical Investigation·Masato KasugaTakeshi Ohara
Nov 16, 2005·Annual Review of Genetics·John C LucchesiBarbara Panning
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·S Shenolikar, D L Brautigan
Dec 17, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·M K Raghuraman, Bonita J Brewer
May 6, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·R Stewart, D Liolitsa
May 4, 2006·PLoS Biology·Susanna Mlynarczyk-EvansBarbara Panning
May 10, 2007·Nature Protocols·Véronique Azuara
Aug 3, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·N D WilsonE V Volpi
Dec 19, 2019·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Michelle L HulkeAmnon Koren
Oct 7, 2004·Endocrine Reviews·Clara BouchéAllison B Goldfine
Apr 22, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·I Barroso
Aug 5, 2019·Current Diabetes Reports·Ashot Sargsyan, Mark A Herman
Jun 28, 2018·Molecular Genetics and Genomics : MGG·Katy Sánchez-PozosMarta Menjivar
Nov 27, 2020·Cellular and Molecular Life Sciences : CMLS·Essam M Abdelalim
Jan 27, 1998·Methods : a Companion to Methods in Enzymology·B A Boggs, A C Chinault

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.