A Wnt-FoxQ2-nodal pathway links primary and secondary axis specification in sea urchin embryos

Developmental Cell
S YaguchiL M Angerer

Abstract

The primary (animal-vegetal) (AV) and secondary (oral-aboral) (OA) axes of sea urchin embryos are established by distinct regulatory pathways. However, because experimental perturbations of AV patterning also invariably disrupt OA patterning and radialize the embryo, these two axes must be mechanistically linked. Here we show that FoxQ2, which is progressively restricted to the animal plate during cleavage stages, provides this linkage. When AV patterning is prevented by blocking the nuclear function of beta-catenin, the animal plate where FoxQ2 is expressed expands throughout the future ectoderm, and expression of nodal, which initiates OA polarity, is blocked. Surprisingly, nodal transcription and OA differentiation are rescued simply by inhibiting FoxQ2 translation. Therefore, restriction of FoxQ2 to the animal plate is a crucial element of canonical Wnt signaling that coordinates patterning along the AV axis with the initiation of OA specification.

References

Mar 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B T Livingston, F H Wilt
Dec 1, 1985·Molecular and Cellular Biology·G I EvanJ M Bishop
Mar 30, 1973·Experimental Cell Research·S Hörstadius
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A H WikramanayakeW H Klein
Feb 10, 2000·Nature·A F Schier, M M Shen
May 25, 2002·Developmental Biology·Eric H DavidsonHamid Bolouri
May 25, 2002·Developmental Biology·Paola OliveriEric H Davidson
Jan 2, 2003·Current Topics in Developmental Biology·Lynne M Angerer, Robert C Angerer
Feb 6, 2003·Gene·Ian A HopeSobia Aslam
Mar 13, 2003·Development Genes and Evolution·Jr-Kai YuLinda Z Holland
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Alexander F Schier
Jan 28, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hsiu-Hsiang Lee, Manfred Frasch
Mar 11, 2004·Evolution & Development·Yoko NakajimaRobert D Burke
Mar 20, 2004·Developmental Cell·Véronique DubocThierry Lepage
Jun 9, 2004·Gene Expression Patterns : GEP·Takuya MinokawaEric H Davidson
Aug 26, 2004·Developmental Biology·Ochan OtimEric H Davidson
Nov 2, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Vera Lynn FlowersJudith M Venuti
Dec 4, 2004·Methods in Cell Biology·Andrew Ransick
Oct 6, 2006·Development Genes and Evolution·Sandra ChevalierEvelyn Houliston
Nov 4, 2006·Developmental Biology·Qiang TuPaola Oliveri
Nov 11, 2006·Science·Erica SodergrenRita Wright
Nov 15, 2006·Developmental Biology·Shunsuke YaguchiRobert D Burke

❮ Previous
Next ❯

Citations

Dec 22, 2011·Nature Communications·Diane K AdamsLynne M Angerer
Nov 15, 2008·Nature Protocols·Stefan C Materna, Paola Oliveri
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zheng WeiLynne M Angerer
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Amanda B CoreCynthia A Bradham
Oct 9, 2013·EvoDevo·Linda Z HollandJr-Kai Yu
Aug 11, 2011·Development·Lynne M AngererRobert D Burke
Jan 31, 2014·BMC Biology·Heather MarlowDetlev Arendt
Feb 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·Enhu LiEric H Davidson
Jun 19, 2013·Current Opinion in Genetics & Development·M Dolores MolinaThierry Lepage
Jan 23, 2016·Open Biology·Karuna Sampath, Elizabeth J Robertson
May 12, 2009·Biochimica Et Biophysica Acta·Yi-Hsien Su
Feb 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robin P ErtlJames A Coffman
Jan 8, 2011·Evolution & Development·Robert D Burke
Nov 5, 2014·Genesis : the Journal of Genetics and Development·Robert D BurkeValerie J Taylor
Feb 20, 2014·Genesis : the Journal of Genetics and Development·Veronica F Hinman, Alys M Cheatle Jarvela
Feb 20, 2014·Genesis : the Journal of Genetics and Development·Ryan Range
Nov 9, 2010·Mechanisms of Development·Karl-Frederik BergeronBruce P Brandhorst
Mar 11, 2015·Development, Growth & Differentiation·Shunsuke YaguchiJunko Yaguchi
Aug 1, 2013·Gene Expression Patterns : GEP·Brenna S McCauleyVeronica F Hinman
Sep 30, 2010·Developmental Biology·Shunsuke YaguchiKazuo Inaba
Aug 17, 2010·Developmental Biology·Shunsuke YaguchiRobert D Burke
Apr 7, 2015·Molecular Biology and Evolution·Hendrik O PetersenThomas W Holstein
Jan 24, 2015·Developmental Biology·Nadezda StepichevaJia L Song
Apr 25, 2009·Developmental Biology·Cynthia A BradhamAlbert J Poustka
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Miao CuiIsabelle S Peter
Apr 14, 2009·Current Topics in Developmental Biology·Rudolf A Raff, Margaret Snoke Smith
Nov 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Eric M Erkenbrack
Apr 23, 2016·PLoS Genetics·Junko YaguchiShunsuke Yaguchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cell Fate Specification

Cell fate specification is determined by complex signal transduction pathways including Notch and the Sonic hedgehog signaling pathway. Here is the latest research on regulation of cell fate determination.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.