A Wolbachia-Sensitive Communication between Male and Female Pupae Controls Gamete Compatibility in Drosophila

Current Biology : CB
Stéphanie M Pontier, François Schweisguth

Abstract

Gamete compatibility is fundamental to sexual reproduction. Wolbachia are maternally inherited endosymbiotic bacteria that manipulate gamete compatibility in many arthropod species. In Drosophila, the fertilization of uninfected eggs by sperm from Wolbachia-infected males often results in early developmental arrest. This gamete incompatibility is called cytoplasmic incompatibility (CI). CI is highest in young males, suggesting that Wolbachia affect sperm properties during male development. Here, we show that Wolbachia modulate testis development. Unexpectedly, this effect was associated with Wolbachia infection in females, not males. This raised the possibility that females influenced testis development by communicating with males prior to adulthood. Using a combinatorial rearing protocol, we provide evidence for such a female-to-male communication during metamorphosis. This communication involves the perception of female pheromones by male olfactory receptors. We found that this communication determines the compatibility range of sperm. Wolbachia interfere with this female-to-male communication through changes in female pheromone production. Strikingly, restoring this communication partially suppressed CI in Wolbachia-infected...Continue Reading

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Citations

Dec 17, 2016·Journal of Evolutionary Biology·S N Gershman, H D Rundle
Jan 25, 2017·Current Biology : CB·Angelo JacquetBenjamin Loppin
Jan 25, 2017·Current Biology : CB·Stephanie M Pontier, François Schweisguth
Mar 23, 2018·Natural Product Reports·Tobias Engl, Martin Kaltenpoth
Apr 8, 2020·The Journal of Experimental Biology·Rohini Singh, Timothy A Linksvayer
Nov 21, 2018·Behavior Genetics·Daniela I SchneiderWolfgang J Miller
Feb 9, 2021·Microbial Ecology·Weihao DouDawei Huang
Jan 28, 2019·Trends in Genetics : TIG·John F BeckmannSylvain Charlat

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