A work flow to build and validate patient specific left atrium electrophysiology models from catheter measurements

Medical Image Analysis
Cesare CorradoSteven A Niederer

Abstract

Biophysical models of the atrium provide a physically constrained framework for describing the current state of an atrium and allow predictions of how that atrium will respond to therapy. We propose a work flow to simulate patient specific electrophysiological heterogeneity from clinical data and validate the resulting biophysical models. In 7 patients, we recorded the atrial anatomy with an electroanatomical mapping system (St Jude Velocity); we then applied an S1-S2 electrical stimulation protocol from the coronary sinus (CS) and the high right atrium (HRA) whilst recording the activation patterns using a PentaRay catheter with 10 bipolar electrodes at 12 ± 2 sites across the atrium. Using only the activation times measured with a PentaRay catheter and caused by a stimulus applied in the CS with a remote catheter we fitted the four parameters for a modified Mitchell-Schaeffer model and the tissue conductivity to the recorded local conduction velocity restitution curve and estimated local effective refractory period. Model parameters were then interpolated across each atrium. The fitted model recapitulated the S1-S2 activation times for CS pacing giving a correlation ranging between 0.81 and 0.98. The model was validated by co...Continue Reading

Citations

Oct 27, 2018·Nature Reviews. Cardiology·Steven A NiedererNatalia A Trayanova
Feb 23, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Dominic G WhittakerGary R Mirams
May 26, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·S A NiedererL Wang
May 26, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Richard H ClaytonRodrigo Weber Dos Santos
May 26, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Sam CoveneyRichard D Wilkinson
May 28, 2020·Annals of Biomedical Engineering·Caroline H RoneySteven A Niederer
Jul 21, 2020·Arrhythmia & Electrophysiology Review·Caroline H RoneyNicholas S Peters
Jan 14, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Cesare CorradoSteven Niederer
Mar 23, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Patrick M BoyleNatalia A Trayanova
Feb 14, 2019·International Journal of Cardiology·Konstantinos N AronisNatalia A Trayanova
Oct 8, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Cesare CorradoSteven A Niederer
Jun 26, 2021·Computer Methods and Programs in Biomedicine·Gernot PlankEdward J Vigmond
Oct 26, 2020·Computers in Biology and Medicine·Simone StellaAlfio Quarteroni
Apr 1, 2021··Rahul MangharamSanjay Dixit

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Software Mentioned

VMTK
Ensite Velocity St Jude
VTK
CNR
Cardiac Arrhythmias Package ( CARP )
MATLAB
MESHLAB

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