A worrying trend in weight-adjusted paediatric antibiotic use in a Norwegian tertiary care hospital

Acta Paediatrica
Ragnhild RaastadFredrik Müller

Abstract

The World Health Organization recommends the defined daily dose (DDD) as the standard unit of measurement for antibiotic use, but this is not applicable in children. We aimed to assess paediatric antibiotic use in a Norwegian tertiary care hospital using a novel weight-adjusted method. We obtained antibiotic purchase data from the hospital pharmacy and administrative data for all admissions from 2002 to 2009 to the paediatric wards at Oslo University Hospital, Rikshospitalet. Recommended daily doses per 100 kg days (RDDs/kg days) were calculated based on national guidelines for paediatric antibiotic use, length of stay and estimated weight for sex and age using national growth references. Total antibiotic use increased significantly from 51.8 to 65.5 RDDs/100 kg days. We found statistically significant annual increases in the consumption of carbapenems (18.0%), third-generation cephalosporins (6.0%) and imidazole derivatives (6.6%) and a considerable difference between total antibiotic use measured in RDDs/100 kg days and DDDs/100 bed days for neonates. Weight-adjusted antibiotic use provided a more meaningful description of the quantities of antibiotics consumed than DDDs/100 bed days, particularly for neonates. Total antibiot...Continue Reading

References

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Citations

Aug 25, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Dag Berild
May 12, 2018·The Pediatric Infectious Disease Journal·Christian Magnus ThaulowHege Salvesen Blix
Mar 19, 2019·The Pediatric Infectious Disease Journal·Christian Magnus ThaulowHege Salvesen Blix

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