A WT1 protein-derived, naturally processed 16-mer peptide, WT1(332), is a promiscuous helper peptide for induction of WT1-specific Th1-type CD4(+) T cells

Microbiology and Immunology
Fumihiro FujikiH Sugiyama

Abstract

The Wilms' tumor gene WT1 is overexpressed in various tumors, and the WT1 protein has been demonstrated to be an attractive target antigen for cancer immunotherapy. A WT1 protein-derived 16-mer peptide, WT1(332) (KRYFKLSHLQMHSRKH), which was naturally generated through processing in cells and could elicit Th1-type CD4(+) helper T cell responses with an HLA-DRB1*0405-restriction has previously been identified by us. In the present study, it has been demonstrated that WT1(332) can induce WT1(332)-specific CD4(+) T cell responses with the restriction of not only HLA-DRB1*0405 but also HLA-DRB1*1501, -DRB1*1502, or -DPB1*0901. These HLA class II-restricted WT1(332)-specific CD4(+) T cell lines produced IFN-gamma but neither IL-4 nor IL-10 with WT1(332) stimulation, thus showing a Th1-type cytokine profile. Furthermore, HLA-DRB1*1501 or -DRB1*1502-restricted WT1(332)-specific CD4(+) T cell lines responded to WT1-expressing transformed cells in an HLA-DRB1-restricted manner, which is consistent with our previous finding that WT1(332) is a naturally processed peptide. These results indicate that the natural peptide, WT1(332), is a promiscuous WT1-specific helper epitope. WT1(332) is expected to apply to cancer patients with various ty...Continue Reading

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Citations

Jan 1, 2013·Cancer Immunology, Immunotherapy : CII·Sho TachinoHaruo Sugiyama
Apr 17, 2010·Japanese Journal of Clinical Oncology·Haruo Sugiyama
Jan 13, 2018·International Journal of Cancer. Journal International Du Cancer·Yusuke OjiHaruo Sugiyama
Aug 2, 2013·Breast Care·Carmen Criscitiello
Mar 18, 2009·The Oncologist·Evelien L J M SmitsViggo F I Van Tendeloo
Feb 17, 2011·Expert Review of Hematology·Gheath Alatrash, Jeffrey J Molldrem
Jul 25, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shigeo KoidoHisao Tajiri

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