A yeast glycolipid biosurfactant, mannosylerythritol lipid, shows potential moisturizing activity toward cultured human skin cells: the recovery effect of MEL-A on the SDS-damaged human skin cells

Journal of Oleo Science
Tomotake MoritaDai Kitamoto

Abstract

Mannosylerythritol lipids (MELs) are produced in large amounts from renewable vegetable oils by Pseudozyma antarctica, and are the most promising biosurfactants known due to its versatile interfacial and biochemical actions. In order to broaden the application in cosmetics and pharmaceuticals, the skin care property of MEL-A, the major component of MELs, was investigated using a three-dimensional cultured human skin model. The skin cells were cultured and treated with sodium dodecyl sulfate (SDS) solution of 1 wt%, and the effects of different lipids on the SDS-damaged cells were then evaluated on the basis of the cell viability. The viability of the damaged cells was markedly recovered by the addition of MEL-A in a dose-dependent manner. Compared to the control, MEL-A solutions of 5 wt% and 10 wt% gave the recovery rate of 73% and 91%, respectively, while ceramide solution of 1 wt% gave the rate of over 100%. This revealed that MEL-A shows a ceramide-like moisturizing activity toward the skin cells. Considering the drawbacks of natural ceramides, namely limited amount and high production cost, the yeast biosurfactants should have a great potential as a novel moisturizer for treating the damaged skin.

References

Jul 13, 2004·Applied Microbiology and Biotechnology·U RauS Lang
Oct 20, 2005·Journal of Bioscience and Bioengineering·Dai KitamotoTadaatsu Nakahara
Dec 24, 2005·Chemistry : a European Journal·Tomohiro ImuraDai Kitamoto
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Tomohiro ImuraDai Kitamoto
Apr 4, 2009·Biotechnology and Applied Biochemistry·Tomotake MoritaDai Kitamoto

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Citations

Apr 29, 2010·Applied Microbiology and Biotechnology·Ibrahim M BanatRoger Marchant
Apr 16, 2013·Applied Microbiology and Biotechnology·Tomotake MoritaDai Kitamoto
Sep 26, 2012·Dermatology Research and Practice·M Catherine Mack Correa, Judith Nebus
May 1, 2010·Journal of Oleo Science·Tomotake MoritaDai Kitamoto
Jul 14, 2010·Journal of Oleo Science·Tomotake MoritaDai Kitamoto
Apr 26, 2012·Journal of Oleo Science·Tokuma FukuokaDai Kitamoto
Mar 12, 2011·Journal of Bioscience and Bioengineering·Masaaki KonishiYuji Hatada
Mar 10, 2015·Journal of Oleo Science·Tomotake MoritaDai Kitamoto
Apr 22, 2015·Journal of Oleo Science·Tokuma FukuokaHiroko Kitamoto
Sep 12, 2015·Carbohydrate Research·Mnif Inès, Ghribi Dhouha
Jan 15, 2015·Applied Microbiology and Biotechnology·Michael GüntherSteffen Rupp
Jan 13, 2017·Critical Reviews in Biotechnology·X VecinoL R Rodrigues
Nov 16, 2018·Journal of Oleo Science·Tokuma FukuokaHiroshi Habe
Mar 2, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Il-Hong BaeDae-Yong Kim
Mar 7, 2021·International Journal of Molecular Sciences·Ana B MoldesJosé M Cruz
Jul 30, 2021·Journal of Industrial Microbiology & Biotechnology·Alexander BeckSusanne Zibek

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