A Young Child with Eosinophilia, Rash, and Multisystem Illness: Drug Rash, Eosinophilia, and Systemic Symptoms Syndrome After Receipt of Fluoxetine

Pediatric Dermatology
Pandiarajan VigneshApurba Ghosh

Abstract

Drug rash, eosinophilia, and systemic symptoms (DRESS) syndrome is a severe systemic hypersensitivity reaction that usually occurs within 6 weeks of exposure to the offending drug. Diagnosis is usually straightforward in patients with pyrexia, skin rash, hepatitis, and eosinophilia with a preceding history of exposure to agents often associated with DRESS syndrome, such as aromatic anticonvulsants and sulfa drugs, but diagnosis of DRESS may still be a challenge. We report a 4-year-old child with probable DRESS syndrome complicated by multiple hematologic complications that developed 1 month after exposure to fluoxetine, a drug not known to be associated with such severe reactions.

References

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Citations

Mar 10, 2018·Hospital Practice·Sapan Kumar BeheraSandhiya Selvarajan
Aug 20, 2019·Pediatric Dermatology·Kate E OberlinAnita N Haggstrom
Apr 6, 2020·Journal of the American Academy of Dermatology·Grace Y KimMegha M Tollefson

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