A Zika virus-associated microcephaly case with background exposure to STORCH agents

BioRxiv : the Preprint Server for Biology
Mauro M HanaokaPaolo Marinho de Andrade Zanotto


We present a case of microcephaly associated with Zika virus (ZIKV) in a chronological, multimodal imaging approach, illustrating the hallmarks of this disease on intrauterine morphological ultrasound, transfontanelar ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI). We also determined the serological e immunological status of the mother and newborn. Noticeably, there was evidence for maternal infection by ZIKV, cytomegalovirus (CMV), herpes simplex virus (HSV), dengue virus (DENV) and Toxoplasma gondii, which indicates a possible role of previous exposures to STORCH agents and possibly comorbidities in the severe fetal congenital manifestation.

Related Concepts

Dengue Virus
Magnetic Resonance Imaging
X-Ray Computed Tomography
Toxoplasma gondii
Zika virus (organism)
Human herpes simplex virus
Pharmacologic Substance
Multimodal Imaging

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