A1 adenosine receptors differentially regulate the N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated components of hippocampal excitatory postsynaptic current in a Ca2+/Mg(2+)-dependent manner

Neuroscience
A KlishinO Krishtal

Abstract

A1 adenosine receptors efficiently modulate the excitatory synaptic transmission in hippocampus. Here we report that in addition to previously known modulatory action on the synaptic efficacy, A1 adenosine receptors are also capable of regulating the relative contribution of N-methyl-D-aspartate receptor-mediated component of the excitatory postsynaptic current in CA3-CA1 excitatory synapses, in the rat. When applied externally, a selective A1 adenosine receptor antagonist, 8-cyclopentyl-1,3-dimethylxanthine, increases not only the amplitude of excitatory postsynaptic current but also the relative contribution of the N-methyl-D-aspartate receptor-mediated component of postsynaptic current recorded by in situ voltage clamp. This effect develops only at increased external Ca2+ concentration and also depends on the external Ca2+/Mg2+ ratio. The increased ratio of N-methyl-D-aspartate/non-N-methyl-D-aspartate components of excitatory postsynaptic current remains at a new level after the removal of 8-cyclopentyl-1,3-dimethylxanthine, even though the amplitude of excitatory postsynaptic current returns close to control value. These results indicate the existence of a mechanism that preferentially enhances the N-methyl-D-aspartate com...Continue Reading

References

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Citations

Feb 13, 1999·European Journal of Pharmacology·D K Von Lubitz
Jun 4, 1999·European Journal of Pharmacology·D K von Lubitz
Sep 30, 2000·Brain Research. Brain Research Reviews·A de MendonçaJ A Ribeiro
Mar 30, 2010·The European Journal of Neuroscience·Alexandra L Ferguson, Trevor W Stone
Dec 15, 2010·Biochimica Et Biophysica Acta·Catarina V GomesRodrigo A Cunha
Oct 14, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Troy A Hackett
May 20, 2006·The Journal of Pharmacology and Experimental Therapeutics·Sergei MelnikNatalia Lozovaya
Jul 2, 2016·Journal of Neurochemistry·Rodrigo A Cunha
Sep 29, 2019·Journal of Caffeine and Adenosine Research·Mariana Temido-FerreiraLuísa V Lopes
Feb 20, 2021·Pharmacology & Therapeutics·Aleksandra SzopaPiotr Wlaź
Apr 29, 2021·Signal Transduction and Targeted Therapy·Zhao HuangYong Tang

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