A1 toxicity in yeast. A role for Mg?

Plant Physiology
C W MacDiarmid, Richard C Gardner

Abstract

We have established conditions in which soluble Al is toxic to the yeast Saccharomyces cerevisiae. The major modifications to a standard synthetic medium were lowering the pH and the concentration of Mg ions. Alterations to the PO4, Ca, or K concentration had little effect on toxicity. Organic acids known to chelate Al reduced its toxicity, suggesting that Al3+ is the toxic Al species. The unique ability of Mg ions to ameliorate Al toxicity led us to investigate the hypothesis that Al inhibits Mg uptake by yeast. Yeast cells accumulate Mg, Co, Zn, Ni, and Mn ions via the same transport system (G.F. Fuhrmann, A. Rothstein [1968] Biochim Biophys Acta 163: 325-330). Al3+ inhibited the accumulation of 57Co2+ by yeast cells more effectively than Ga, La, or Mg. In addition, a mutant yeast strain with a defect in divalent cation uptake proved to be more sensitive to Al than a wild-type strain. Taken together, these results suggest that Al may cause Mg deficiency in yeast by blocking Mg transport. We discuss the relevance of yeast as a model for the study of Al toxicity in plant systems.

References

May 16, 1977·European Journal of Biochemistry·L A OkorokovI S Kulaev
Jan 1, 1991·Journal of Cellular Biochemistry·R K Mehra, D R Winge
Apr 10, 1987·Science·T L MacdonaldR B Martin
Dec 1, 1981·Biochimica Et Biophysica Acta·G W Borst-Pauwels
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·S KushnirD Inzé

❮ Previous
Next ❯

Citations

Dec 6, 2005·Current Genetics·Jong-Min Lee, Richard C Gardner
Dec 30, 2008·Journal of Industrial Microbiology & Biotechnology·Yuan LiNorio Sugiura
Oct 6, 2007·Biological Trace Element Research·Taisuke SuzukiEtsuro Yoshimura
Dec 26, 2001·The Plant Cell·L LiS Luan
Sep 21, 2004·Annual Review of Plant Biology·Leon V KochianMiguel A Pineros
Jul 9, 2011·PloS One·Phaik Har LimColin W MacDiarmid
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·G BorrellyR Gibrat
Feb 3, 2009·Archives of Environmental Contamination and Toxicology·Ricardo Pinheiro de Souza OliveiraAttilio Converti
May 14, 2014·Journal of Experimental Botany·Jixing XiaJian Feng Ma
Dec 7, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Raymond J Ritchie, Shyam Sundar Raghupathi
Apr 19, 2005·Journal of Inorganic Biochemistry·Atsushi KobayashiEtsuro Yoshimura
Oct 1, 2014·BMC Plant Biology·Huanhuan ZhangDonghua Liu
Jan 27, 1998·The Journal of Biological Chemistry·C W MacDiarmid, R C Gardner
Feb 1, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Toshiyoshi YamamotoMichio Suzuki
Jul 31, 2020·Canadian Journal of Microbiology·Ranran ChenPing Shi
Apr 15, 2003·Neuroreport·Huguette C Politi, Robin R Preston

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.