A118G polymorphism of OPRM1 gene is associated with schizophrenia.

Journal of Molecular Neuroscience : MN
Omar SerýFrantisek St'astný

Abstract

Schizophrenia is ranked among multifactor diseases in whose pathogenesis, besides environmental factors, an interplay of functional polymorphisms of a larger number of candidate genes is involved. Neurodevelopmental abnormities are among the most accepted hypotheses in the etiology of schizophrenia. Recently, the role of oligodendrocytes in the development of the cortex has been cited repeatedly. During their various phases of differentiation oligodendrocytes present on their surfaces diverse receptors, among others the mu-opioid receptor (OPRM1). The study was focused on the relationship between the functional A118G polymorphism of the OPRM1 gene (rs1799971) and schizophrenia in groups of 130 male patients and 452 male controls. An association study revealed yet unpublished statistically significant difference of allelic and genotypic frequencies between the control and patient groups. According to our present knowledge, we assume that the OPRM1 gene polymorphism can influence the myelination of CNS neurons through regulations of expression of OPRM1 receptors on surfaces of oligodendrocytes. The neuronal myelination seems to be one of the important factors in the pathogenesis of schizophrenia.

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Citations

Sep 17, 2011·Pharmacogenomics·Shinya Kasai, Kazutaka Ikeda
Dec 12, 2012·Trends in Neurosciences·Pierre-Eric Lutz, Brigitte L Kieffer
Jun 28, 2019·Arhiv za higijenu rada i toksikologiju·Hülya TürkanAli Esat Karakaya
Feb 20, 2020·Current Opinion in Psychiatry·Kevin J LiLynn E DeLisi
May 23, 2020·Neuropsychiatric Disease and Treatment·Klara LatalovaLadislav Hosak
Apr 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sarah E MorganEdward T Bullmore
Sep 29, 2019·International Journal of Molecular Sciences·Aline HajjSouheil Hallit
Mar 25, 2020·Cold Spring Harbor Perspectives in Medicine·Brian Reed, Mary Jeanne Kreek

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