A20 overexpression exerts protective effects on podocyte injury in lupus nephritis by downregulating UCH-L1

Journal of Cellular Physiology
Ling SunPo Hu

Abstract

Lupus nephritis (LN), an autoimmune kidney disease caused by systemic lupus erythematosus (SLE), is the inflammation of the kidney. Although the treatment of LN is still a therapeutic challenge for many practitioners, the present study aims to provide a new insight for the treatment and management. The study aims to explore the effect of A20 on LN in relation to the nuclear factor-kappa B (NF-κB) signaling pathway. MRL/lpr mice were used as the LN mouse model. Next, A20, UCH-L1, and NF-κB expression in LN patients and MRL/lpr mice was determined. A20 was upregulated in podocytes to assess biological functions of A20 in LN. Furthermore, to further investigate the pivotal role of the NF-κB pathway in LN, the NF-κB pathway was blocked in podocytes. Next, UCH-L1 was downregulated in MRL/lpr mice to assess biological functions of UCH-L1 in LN. A20 was downregulated, whereas UCH-L1 was upregulated in LN. Overexpressed A20 declined NF-κB, UCH-L1 expression, and the extent of p65 phosphorylation. A20 overexpression or UCH-L1 inhibition increased expression of synaptoporin and nephrin but decreased desmin expression and ubiquitin accumulation level in podocytes. Moreover, A20 overexpression or UCH-L1 inhibition increased the podocyte nu...Continue Reading

References

Oct 22, 2004·Kidney International·José G van den BergSandrine Florquin
Sep 17, 2005·Kidney International·Takehiko WadaStuart J Shankland
Feb 14, 2009·The Journal of Pathology·Yuan LiuZhigang Zhang
Dec 2, 2009·Nature Reviews. Rheumatology·Anne Davidson, Cynthia Aranow
Feb 11, 2010·Neurochemistry International·Takeshi MitsuiKeiji Wada
Feb 19, 2010·Biology of Reproduction·Andrej SusorMichal Kubelka
Mar 2, 2010·Arthritis Care & Research·Mikkel FaurschouSøren Jacobsen
Jun 10, 2010·The Journal of Experimental Medicine·Lars VereeckeGeert van Loo
Jul 6, 2010·Biochemical Pharmacology·Lynn VerstrepenRudi Beyaert
Feb 12, 2011·Cancer Letters·Min Jung JangJung Hwa Kim
Jun 21, 2011·The American Journal of the Medical Sciences·Hala AlshayebElvira O Gosmanova
Sep 10, 2011·Journal of Biomedicine & Biotechnology·Katsuhisa MiyakeHitoshi Nakashima
Nov 22, 2011·Molecular Cell·Brian SkaugZhijian J Chen
Jul 17, 2012·Trends in Neurosciences·Marcello D'AmelioFrancesco Cecconi
Mar 26, 2013·Journal of Neuroimmunology·Gabriela Ravanelli Oliveira-PelegrinMaria José Alves Rocha
Apr 10, 2013·Cellular Signalling·Hongxia ZhangZhigang Zhang
Jun 19, 2013·International Immunopharmacology·Jijun ZhaoNiansheng Yang
Jul 6, 2014·Rheumatology·Desmond Y H YapTak Mao Chan
Nov 11, 2014·Annals of Internal Medicine·Zhihong LiuMinlin Zhou
May 16, 2015·Molecular Medicine Reports·Hongxia ZhangZhigang Zhang
Feb 26, 2016·Oncotarget·Xianteng WangYongyu Shi
Apr 20, 2016·Clinical and Experimental Nephrology·Maho YamashitaMatsuhiko Hayashi
Aug 28, 2016·Physiological Reports·Maho YamashitaMatsuhiko Hayashi
Aug 30, 2016·International Journal of Molecular Sciences·Hongxia ZhangShijun Lv
Jun 29, 2017·PloS One·Anri AkiTakashi Kagari
Nov 17, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wenjing XuKai Huang

❮ Previous
Next ❯

Citations

Nov 23, 2019·Journal of Receptor and Signal Transduction Research·Nguyen Thi XuanNguyen Huy Hoang
Sep 1, 2019·Journal of Clinical Medicine·Hamza SakhiKhalil El Karoui
Mar 29, 2020·Frontiers in Immunology·Yajie LiSinem Esra Sahingur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.