PMID: 9445060Jan 28, 1998Paper

A27L protein mediates vaccinia virus interaction with cell surface heparan sulfate

Journal of Virology
C S ChungW Chang

Abstract

Vaccinia virus has a wide host range and infects mammalian cells of many different species. This suggests that the cell surface receptors for vaccinia virus are ubiquitously expressed and highly conserved. Alternatively, different receptors are used for vaccinia virus infection of different cell types. Here we report that vaccinia virus binds to heparan sulfate, a glycosaminoglycan (GAG) side chain of cell surface proteoglycans, during virus infection. Soluble heparin specifically inhibits vaccinia virus binding to cells, whereas other GAGs such as condroitin sulfate or dermantan sulfate have no effect. Heparin also blocks infections by cowpox virus, rabbitpox virus, myxoma virus, and Shope fibroma virus, suggesting that cell surface heparan sulfate could be a general mediator of the entry of poxviruses. The biochemical nature of the heparin-blocking effect was investigated. Heparin analogs that have acetyl groups instead of sulfate groups also abolish the inhibitory effect, suggesting that the negative charges on GAGs are important for virus infection. Furthermore, BSC40 cells treated with sodium chlorate to produce undersulfated GAGs are more refractory to vaccinia virus infection. Taken together, the data support the notion ...Continue Reading

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Citations

Mar 23, 2000·Journal of Virology·C L AfonsoD L Rock
Sep 27, 2003·Journal of Virology·A KernJ A Kleinschmidt
Apr 16, 2005·The Journal of General Virology·Gemma C CarterGeoffrey L Smith
Jul 16, 2005·Annals of Medicine·Sigvard Olofsson, Tomas Bergström
Feb 14, 2007·Veterinary Research·Marianne M StanfordGrant McFadden
Jul 21, 2007·The Journal of Biological Chemistry·Maren KnappeMartin Sapp
Feb 22, 2012·Journal of Virology·Nina SchroederWen Chang
Feb 8, 2013·Journal of Virology·Winnie M ChanGrant McFadden
Jan 11, 2013·Journal of Virology·Beatriz SalvadorGraham Simmons
Apr 5, 2013·Biological Reviews of the Cambridge Philosophical Society·Eyal KamhiRobert J Linhardt
May 26, 2016·Journal of Wildlife Diseases·Nadia F Gallardo-RomeroDarin S Carroll
Oct 24, 2000·Journal of Virology·L K HallakM E Peeples
May 17, 2000·The Journal of General Virology·J Schneider-Schaulies
Nov 16, 2001·Animal Health Research Reviews·E Escribano-RomeroV Ley
Aug 31, 2006·Journal of Virology·Alan C TownsleyBernard Moss
Jun 4, 2004·Expert Opinion on Biological Therapy·Z Sheng Guo, David L Bartlett
May 14, 2005·Journal of Virology·Nicole A PattersonMichelle A Ozbun
Jul 15, 2005·Journal of Virology·Alan C TownsleyBernard Moss
Feb 2, 2010·Expert Reviews in Molecular Medicine·Allison H Bartlett, Pyong Woo Park

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