AA Amyloid Deposition in the Central and Peripheral Nervous Systems in Flamingos.

Veterinary Pathology
Ayumi OnoTomoaki Murakami

Abstract

AA amyloidosis is characterized by amyloid deposition in systemic organs, but amyloid deposition in the central nervous system (CNS) or peripheral nervous system (PNS) is rare. In this study, AA amyloidosis was observed in 31 of 48 flamingos that died at a Japanese zoo. Almost all cases developed AA amyloidosis secondary to inflammatory diseases such as enteritis. Affected flamingos had AA amyloid deposition around blood vessels in periventricular white matter of the brain and in peripheral nerves. In addition, cerebral Aβ amyloidosis was observed in one of the 31 cases with AA amyloidosis. In conclusion, flamingos in the zoo commonly developed systemic amyloidosis with frequent amyloid deposition in the CNS and PNS, which seems to be a unique distribution in this avian species. Comparative pathological analyses in flamingos may help elucidate the pathogenesis of amyloid neuropathy.

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Citations

Aug 14, 2020·The Journal of Veterinary Medical Science·Yumiko Nakano, Hiroo Madarame
Apr 23, 2021·The Journal of Veterinary Medical Science·Hiroto KobayashiTomoaki Murakami
Jun 17, 2021·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Hailey B PenticoffJessica S Fortin

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GraphPad Prism8
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