Abstract
A 73-year-old man with a 16-year history of fasciculations and 15 years of weakness in his right arm was diagnosed with focal motor neuron disease. After 10 years of purely motor symptoms, he developed mild parasthesias although his sensory examination remained normal. Reflexes were reduced or absent in the weak muscles but were normal elsewhere. Nerve conduction was studied in nerves innervating weak muscles and showed severe motor conduction block. Sensory nerve conduction studies were minimally abnormal, showing reduced amplitudes with normal velocities. Based on the clinical picture and the presence of severe motor conduction block, the patient was diagnosed as multifocal motor neuropathy. Treatment with high-dose intravenous immunoglobulin was given with significant improvement in strength and partial resolution of the conduction block. As this case demonstrates, this treatable disorder may occasionally be mistaken for motor neuron disease although the resemblance is only superficial, and it should never be mistaken for amyotrophic lateral sclerosis. Multifocal motor neuropathy is an inflammatory, demyelinating neuropathy which, like chronic inflammatory demyelinating polyneuropathy (CIDP), is probably immune-mediated. It ...Continue Reading
References
Dec 1, 1992·Muscle & Nerve·M Hallett
Mar 1, 1992·Neurology·R KajiJ Kimura
Jan 1, 1990·Neurology·C KrarupS A Lipton
Mar 1, 1990·Annals of Neurology·A PestronkW C Yee
Nov 1, 1987·Electroencephalography and Clinical Neurophysiology·G Roth, M R Magistris
May 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R N AuerM A Lee
Jan 1, 1989·Muscle & Nerve·P Van den BerghJ J Kelly
Apr 1, 1988·Archives of Neurology·W G BradleyB Little
Jul 1, 1988·Annals of Neurology·A PestronkR N Adams
Feb 1, 1988·Muscle & Nerve·G J Parry, S Clarke
Sep 1, 1982·Neurology·R A LewisA K Asbury
Feb 1, 1994·Muscle & Nerve·V ChaudhryJ W Griffin
Mar 1, 1994·Neurology·J P AzulayG Serratrice
Jan 1, 1994·Muscle & Nerve·A J Kornberg, A Pestronk
Jan 1, 1994·Muscle & Nerve·D J Lange, W Trojaborg
Jan 1, 1994·Muscle & Nerve·R KajiJ Kimura
Jan 1, 1994·Muscle & Nerve·G J Parry
Sep 1, 1993·Seminars in Neurology·G J Parry
Feb 1, 1994·Archives of Neurology·E TanJ R Mendell
Jan 1, 1993·Muscle & Nerve·S G Waxman
Feb 1, 1993·Annals of Neurology·R KajiJ Kimura
Mar 1, 1993·Neurology·E Nobile-OrazioG Scarlato
Mar 1, 1993·Annals of Neurology·V ChaudhryJ W Griffin
Citations
Sep 5, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·A LaguenyP Deliac
Nov 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·J-P LefaucheurA Créange
Apr 5, 2008·American Journal of Physical Medicine & Rehabilitation·David BrownThomas Strax
Aug 10, 2000·Italian Journal of Neurological Sciences·G Comi, L Roveri
Nov 23, 2011·Nature Reviews. Neurology·Lotte VlamLeonard H van den Berg
Jul 24, 2002·Brain : a Journal of Neurology·R M Van den Berg-VosL H Van den Berg
Dec 5, 2000·Muscle & Nerve·K Boonyapisit, B Katirji
Sep 20, 2001·Muscle & Nerve·M EurelingsL H van den Berg
Jan 28, 2003·Muscle & Nerve·Alan PestronkMuhammad T Al-Lozi
Jan 8, 2009·Muscle & Nerve·Virginie LambrecqAlain Lagueny
Mar 5, 1998·Muscle & Nerve·D L MenkesD A Williams
Apr 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·G ComiL Leocani
Jul 23, 2003·Muscle & Nerve·R VeltkampH-M Meinck
Feb 19, 1999·Muscle & Nerve·K C GorsonC B Saper
Feb 19, 1999·Muscle & Nerve·H FranssenJ H Wokke
Jan 20, 2000·Muscle & Nerve·P Y Van den BerghE C Laterre
May 19, 1998·Muscle & Nerve·S R Beydoun
Apr 30, 2013·Muscle & Nerve·Antonino UnciniMargherita Capasso
Apr 23, 2005·The Cochrane Database of Systematic Reviews·I N van SchaikM Vermeulen
Jun 17, 1999·Neurology·D J LikoskyE C Yuen
Sep 10, 2003·Neurology·M CapassoA Uncini