a/alpha-specific effect on the mms3 mutation on ultraviolet mutagenesis in Saccharomyces cerevisiae.

Journal of Bacteriology
P MartinS Prakash

Abstract

A new gene involved in error-prone repair of ultraviolet (UV) damage has been identified in Saccharomyces cerevisiae by the mms3-1 mutation. UV-induced reversion is reduced in diploids that are homozygous for mms3-1, only if they are also heterozygous (MATa/MAT alpha) at the mating type locus. The mms3-1 mutation has no effect on UV-induced reversion either in haploids or MATa/MATa or MAT alpha/MAT alpha diploids. The mutation confers sensitivity to UV and methyl methane sulfonate in both haploids and diploids. Even though mutation induction by UV is restored to wild-type levels in MATa/MATa mms3-1/mms3-1 or MAT alpha/MAT alpha mms3-1/mms3-1 diploids, such strains still retain sensitivity to the lethal effects of UV. Survival after UV irradiation in mms3-1 rad double mutant combinations indicates that mms3-1 is epistatic to rad6-1 whereas non-epistatic interactions are observed with rad3 and rad52 mutants. When present in the homozygous state in MATa/MAT alpha his1-1/his1-315 heteroallelic diploids, mms3-1 was found to lower UV-induced mitotic recombination.

References

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Citations

Apr 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Lawrence
Jan 1, 1985·Molecular & General Genetics : MGG·C W LawrenceR B Christensen
Jan 1, 1985·Molecular & General Genetics : MGG·C W LawrenceR B Christensen
Jul 1, 1985·Mutation Research·N J Sargentini, K C Smith
Oct 1, 1984·Mutation Research·W Siede, F Eckardt

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