PMID: 844877Mar 14, 1977Paper

Aanlysis of the frequency and distribution of sister chromatid exchanges in cultured human lymphocytes

Human Genetics
P E CrossenD A Johnston

Abstract

Lymphocytes from 20 notmal subjects (11 male and 9 female) were examined for the frequency and location of sister chromatid exchanges (SCE) by the BrdU--Giemsa method. The mean frequency of SCE was 6.37 with little significant variation. One subject had a high number of exchanges in chromosome 1 while the remainder showed a random distribution of exchanges between chromosomes. The frequency of exchanges generally increased with chromosome length. However, chromosome 1, 2 and the B group had more exchanges than expected while the E, F and G grous had less than expected. The distribution of exchanges in chromosomes 1, 2 and the B group was non-random with a concentration of exchanges below the centromere and to a lesser extent on the distal portion of the long arm. The majority of exchanges appeared to occur at the junction between the dark and light G bands. It is suggested that the concentration of exchanges may reflect differences in BrdU incorporation along the length of the chromosome.

References

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Citations

Jan 1, 1983·Human Genetics·R Becher, A A Sandberg
Jan 1, 1979·Human Genetics·C PedersenU Merrild
May 1, 1981·Mutation Research·W F Morgan, P E Crossen
Mar 1, 1982·Mutation Research·S M NewmanL J Nunez
Oct 1, 1992·Mutation Research·Z Zhang, J Yang
Jul 1, 1986·Cancer Genetics and Cytogenetics·P R KadamA N Bhisey
Jan 1, 1983·Mutation Research·J CastilloA Carnevale
Jun 1, 1983·Mutation Research·L DalpràG Simoni
Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P S KulkarniL M Ambani
Jun 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P S KulkarniS D Bhandarkar
Jan 1, 1985·Archives of Environmental Health·G W RichmondC H Hine
Sep 1, 1980·Journal of Toxicology and Environmental Health·B Lambert, A Lindblad
Oct 11, 2002·The EMBO Journal·Yukiko M YamashitaShunichi Takeda
Jul 1, 1985·Epilepsia·B SchaumannJ Cervenka
Nov 3, 2009·Journal of Occupational Medicine and Toxicology·Malinee Pongsavee
Dec 1, 1981·Environmental Health Perspectives·M K Conner, N Wald
Apr 8, 2000·Current Opinion in Genetics & Development·K J Marians
Oct 21, 2010·Genes, Chromosomes & Cancer·Leslie HohKaren Sisley
Nov 27, 1998·Journal of Occupational and Environmental Medicine·A D LiebermanJ H Nemenzo
Apr 1, 1979·Journal of Dairy Science·D Di Berardino, R N Shoffner
Jan 1, 1980·Environmental Mutagenesis·A V CarranoD H Moore
Dec 1, 1981·Clinical Genetics·H WaksvikK Berg

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