PMID: 844877Mar 14, 1977Paper

Aanlysis of the frequency and distribution of sister chromatid exchanges in cultured human lymphocytes

Human Genetics
P E CrossenD A Johnston


Lymphocytes from 20 notmal subjects (11 male and 9 female) were examined for the frequency and location of sister chromatid exchanges (SCE) by the BrdU--Giemsa method. The mean frequency of SCE was 6.37 with little significant variation. One subject had a high number of exchanges in chromosome 1 while the remainder showed a random distribution of exchanges between chromosomes. The frequency of exchanges generally increased with chromosome length. However, chromosome 1, 2 and the B group had more exchanges than expected while the E, F and G grous had less than expected. The distribution of exchanges in chromosomes 1, 2 and the B group was non-random with a concentration of exchanges below the centromere and to a lesser extent on the distal portion of the long arm. The majority of exchanges appeared to occur at the junction between the dark and light G bands. It is suggested that the concentration of exchanges may reflect differences in BrdU incorporation along the length of the chromosome.


Oct 27, 1971·Nature: New Biology·K W Jones, G Corneo
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B Weisblum, P L De Haseth
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S A Latt
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R S ChagantiJ German
Jan 1, 1974·Chromosoma·J R Korenberg, E F Freedlender
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·T C HsuG F Saunders
May 1, 1974·Experimental Cell Research·D A Gibson, D M Prescott

❮ Previous
Next ❯


Jan 1, 1983·Human Genetics·R Becher, A A Sandberg
Jan 1, 1979·Human Genetics·C PedersenU Merrild
May 1, 1981·Mutation Research·W F Morgan, P E Crossen
Mar 1, 1982·Mutation Research·S M NewmanL J Nunez
Oct 1, 1992·Mutation Research·Z Zhang, J Yang
Jul 1, 1986·Cancer Genetics and Cytogenetics·P R KadamA N Bhisey
Jan 1, 1983·Mutation Research·J CastilloA Carnevale
Jun 1, 1983·Mutation Research·L DalpràG Simoni
Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P S KulkarniL M Ambani
Jun 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P S KulkarniS D Bhandarkar
Jan 1, 1985·Archives of Environmental Health·G W RichmondC H Hine
Sep 1, 1980·Journal of Toxicology and Environmental Health·B Lambert, A Lindblad
Oct 11, 2002·The EMBO Journal·Yukiko M YamashitaShunichi Takeda
Jul 1, 1985·Epilepsia·B SchaumannJ Cervenka
Nov 3, 2009·Journal of Occupational Medicine and Toxicology·Malinee Pongsavee
Dec 1, 1981·Environmental Health Perspectives·M K Conner, N Wald
Apr 8, 2000·Current Opinion in Genetics & Development·K J Marians
Oct 21, 2010·Genes, Chromosomes & Cancer·Leslie HohKaren Sisley
Nov 27, 1998·Journal of Occupational and Environmental Medicine·A D LiebermanJ H Nemenzo
Apr 1, 1979·Journal of Dairy Science·D Di Berardino, R N Shoffner
Jan 1, 1980·Environmental Mutagenesis·A V CarranoD H Moore
Dec 1, 1981·Clinical Genetics·H WaksvikK Berg

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.