AARS2-related ovarioleukodystrophy: Clinical and neuroimaging features of three new cases

Acta Neurologica Scandinavica
I TagliaMaria Teresa Dotti

Abstract

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), previously known as hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) or pigmentary orthochromatic leukodystrophy (POLD), is the most frequent non-vascular adult-onset leukoencephalopathy. It is caused by autosomal dominant mutations in CSF1R gene. Recently, also autosomal recessive mutations in AARS2 gene were found to be the cause of an adult-onset leukodystrophy with axonal spheroids. Our aim was to achieve a genetic diagnosis in a cohort of CSF1R-negative patients, performing a sequence analysis of AARS2 gene. AARS2 sequencing was performed in 38 CSF1R-negative patients with clinical and magnetic resonance imaging (MRI) findings of adult-onset leukoencephalopathy. Three patients carrying AARS2 compound heterozygous mutations have been found. All patients were female with ovarian failure and leukoencephalopathy. In 2 patients, MRI findings were consistent with previous reports while the third patient showed focal white matter (WM) lesions in the centrum semiovale and the corpus callosum in the absence of extensive involvement and rarefaction of the WM. MRI spectroscopy showed the presence of increased lactate in 2 patients, thu...Continue Reading

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Citations

May 18, 2019·American Journal of Medical Genetics. Part a·Siddharth SrivastavaSakkuBai Naidu
Aug 9, 2019·Endocrinology·Dov TiosanoDavid A Buchner
Dec 17, 2019·Journal of Neurodevelopmental Disorders·Amena Smith FineAli Fatemi
Feb 2, 2019·Molecular Genetics & Genomic Medicine·Yi TangJianping Jia
Oct 20, 2020·Clinical Obstetrics and Gynecology·Rukayat O Akande, Yetunde Ibrahim
Apr 10, 2021·The Application of Clinical Genetics·Daniel W SirkisJennifer S Yokoyama
Apr 28, 2021·Magnetic Resonance Imaging Clinics of North America·Aya Midori TokumaruShigeo Murayma
May 1, 2021·International Journal of Molecular Sciences·Sonia FigucciaPaola Goffrini
May 7, 2021·The Journal of Neuropsychiatry and Clinical Neurosciences·Catalina CosteiRoberta La Piana
Sep 30, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nobuhiko OkamotoKenjiro Kosaki
Dec 7, 2021·Frontiers in Aging Neuroscience·Banglian HuHonghua Zheng

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