Abamectin induces rapid and reversible hypoactivity within early zebrafish embryos

Neurotoxicology and Teratology
Tara D Raftery, David C Volz

Abstract

During early zebrafish embryogenesis, spontaneous tail contractions represent the first sign of locomotion and result from innervation of primary motoneuron axons to target axial muscles. Based on a high-content screen, we previously demonstrated that exposure of zebrafish embryos to abamectin--an avermectin insecticide--from 5-25 hours post-fertilization (hpf) abolished spontaneous activity in the absence of effects on survival and gross morphology. Therefore, the objective of this study was to begin investigating the mechanism of abamectin-induced hypoactivity in zebrafish. Similar to 384-well plates, static exposure of embryos to abamectin from 5-25 hpf in glass beakers resulted in elimination of activity at low micromolar concentrations. However, abamectin did not affect neurite outgrowth from spinal motoneurons and, compared with exposure from 5-25 hpf, embryos were equally susceptible to abamectin-induced hypoactivity when exposures were initiated at 10 and 23 hpf. Moreover, immersion of abamectin-exposed embryos in clean water resulted in complete recovery of spontaneous activity relative to vehicle controls, suggesting that abamectin reversibly activated ligand-gated chloride channels and inhibited neurotransmission. To...Continue Reading

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Citations

Feb 27, 2018·Environmental Science and Pollution Research International·Diogo Ferreira do AmaralGuilherme Malafaia
May 4, 2017·Green Chemistry : an International Journal and Green Chemistry Resource : GC·Pamela D NoyesRobert L Tanguay
May 8, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Sirui LiBin Liu
Oct 27, 2017·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Athir BoukhrissaHamid Aït-Amar
Sep 20, 2020·Bulletin of Environmental Contamination and Toxicology·Özgür Fırat, Ramazan Tutus
Feb 18, 2020·Environmental Science and Pollution Research International·Íris Flávia Sousa GonçalvesDavi Felipe Farias
Oct 3, 2020·Integrated Environmental Assessment and Management·Geonildo Rodrigo DisnerMonica Lopes-Ferreira
Dec 8, 2019·Ecotoxicology and Environmental Safety·Yang LiuHong Zhang
Jun 18, 2017·Toxicology and Applied Pharmacology·Sara M VlietDavid C Volz

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